2. Membrane Transporter/Ion Channel Autophagy
  3. Potassium Channel Autophagy
  4. 4-Hydroxytolbutamide-d9

4-Hydroxytolbutamide-d9  (Synonyms: Hydroxytolbutamide-d9)

Cat. No.: HY-100641S Purity: 99.29%
COA Handling Instructions

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4-Hydroxytolbutamide-d9 is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].

For research use only. We do not sell to patients.

4-Hydroxytolbutamide-d<sub>9</sub> Chemical Structure

4-Hydroxytolbutamide-d9 Chemical Structure

CAS No. : 1185112-19-9

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Based on 1 publication(s) in Google Scholar

Other Forms of 4-Hydroxytolbutamide-d9:

4-Hydroxytolbutamide-d9 Related Antibodies

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Description

4-Hydroxytolbutamide-d9 is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4-Hydroxytolbutamide-d9 Related Antibodies
Molecular Weight

295.40

Formula

C12H9D9N2O4S
CAS No.
Unlabeled CAS

5719-85-7
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(CO)C=C1)(NC(NC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 12 mg/mL (40.62 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3852 mL 16.9262 mL 33.8524 mL
5 mM 0.6770 mL 3.3852 mL 6.7705 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.29%

COA (248 KB) HNMR (295 KB) RP-HPLC (464 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 3.3852 mL 16.9262 mL 33.8524 mL 84.6310 mL
5 mM 0.6770 mL 3.3852 mL 6.7705 mL 16.9262 mL
10 mM 0.3385 mL 1.6926 mL 3.3852 mL 8.4631 mL
15 mM 0.2257 mL 1.1284 mL 2.2568 mL 5.6421 mL
20 mM 0.1693 mL 0.8463 mL 1.6926 mL 4.2316 mL
25 mM 0.1354 mL 0.6770 mL 1.3541 mL 3.3852 mL
30 mM 0.1128 mL 0.5642 mL 1.1284 mL 2.8210 mL
40 mM 0.0846 mL 0.4232 mL 0.8463 mL 2.1158 mL
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4-Hydroxytolbutamide-d9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Hydroxytolbutamide-d91185112-19-9Hydroxytolbutamide-d9Potassium ChannelAutophagyKcsAInhibitorinhibitorinhibit

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