2. Membrane Transporter/Ion Channel Autophagy
  3. Potassium Channel Autophagy
  4. 4-Hydroxytolbutamide

4-Hydroxytolbutamide  (Synonyms: Hydroxytolbutamide)

Cat. No.: HY-100641 Purity: 99.69%
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4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic.

For research use only. We do not sell to patients.

4-Hydroxytolbutamide Chemical Structure

4-Hydroxytolbutamide Chemical Structure

CAS No. : 5719-85-7

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10 mg USD 640 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 4-Hydroxytolbutamide:

4-Hydroxytolbutamide Related Antibodies

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Description

4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].

IC50 & Target

Potassium channel
Molecular Weight

286.35

Formula

C12H18N2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(CO)C=C1)(NC(NCCCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (436.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4922 mL 17.4611 mL 34.9223 mL
5 mM 0.6984 mL 3.4922 mL 6.9845 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4922 mL 17.4611 mL 34.9223 mL 87.3057 mL
5 mM 0.6984 mL 3.4922 mL 6.9845 mL 17.4611 mL
10 mM 0.3492 mL 1.7461 mL 3.4922 mL 8.7306 mL
15 mM 0.2328 mL 1.1641 mL 2.3282 mL 5.8204 mL
20 mM 0.1746 mL 0.8731 mL 1.7461 mL 4.3653 mL
25 mM 0.1397 mL 0.6984 mL 1.3969 mL 3.4922 mL
30 mM 0.1164 mL 0.5820 mL 1.1641 mL 2.9102 mL
40 mM 0.0873 mL 0.4365 mL 0.8731 mL 2.1826 mL
50 mM 0.0698 mL 0.3492 mL 0.6984 mL 1.7461 mL
60 mM 0.0582 mL 0.2910 mL 0.5820 mL 1.4551 mL
80 mM 0.0437 mL 0.2183 mL 0.4365 mL 1.0913 mL
100 mM 0.0349 mL 0.1746 mL 0.3492 mL 0.8731 mL
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4-Hydroxytolbutamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Hydroxytolbutamide5719-85-7HydroxytolbutamidePotassium ChannelAutophagyKcsAMetaboliteTolbutamideCYP2C8CYP2C9sulfonylureaoralantidiabeticInhibitorinhibitorinhibit

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