2. Anti-infection
  3. Bacterial
  4. 4-(tert-Butyl)-benzhydroxamic Acid

4-(tert-Butyl)-benzhydroxamic Acid 

Cat. No.: HY-114818 Purity: 99.49%
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4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively. 4-(tert-Butyl)-benzhydroxamic Acid reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM.

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4-(tert-Butyl)-benzhydroxamic Acid Chemical Structure

4-(tert-Butyl)-benzhydroxamic Acid Chemical Structure

CAS No. : 62034-73-5

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Based on 1 publication(s) in Google Scholar

4-(tert-Butyl)-benzhydroxamic Acid Related Antibodies

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Description

4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively. 4-(tert-Butyl)-benzhydroxamic Acid reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM[1].

IC50 & Target

IC50: 12.5 μM (PqsR in E. coli), 23.6 μM (PqsR in P. aeruginosa), 87.2 μM (virulence factor pyocyanin)[1]
Molecular Weight

193.24

Formula

C11H15NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C=C1)C(C)(C)C)NO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (517.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1749 mL 25.8746 mL 51.7491 mL
5 mM 1.0350 mL 5.1749 mL 10.3498 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.1749 mL 25.8746 mL 51.7491 mL 129.3728 mL
5 mM 1.0350 mL 5.1749 mL 10.3498 mL 25.8746 mL
10 mM 0.5175 mL 2.5875 mL 5.1749 mL 12.9373 mL
15 mM 0.3450 mL 1.7250 mL 3.4499 mL 8.6249 mL
20 mM 0.2587 mL 1.2937 mL 2.5875 mL 6.4686 mL
25 mM 0.2070 mL 1.0350 mL 2.0700 mL 5.1749 mL
30 mM 0.1725 mL 0.8625 mL 1.7250 mL 4.3124 mL
40 mM 0.1294 mL 0.6469 mL 1.2937 mL 3.2343 mL
50 mM 0.1035 mL 0.5175 mL 1.0350 mL 2.5875 mL
60 mM 0.0862 mL 0.4312 mL 0.8625 mL 2.1562 mL
80 mM 0.0647 mL 0.3234 mL 0.6469 mL 1.6172 mL
100 mM 0.0517 mL 0.2587 mL 0.5175 mL 1.2937 mL
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4-(tert-Butyl)-benzhydroxamic Acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-(tert-Butyl)-benzhydroxamic Acid62034-73-5BacterialInhibitorinhibitorinhibit

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