2. PROTAC MAPK/ERK Pathway GPCR/G Protein
  3. PROTACs Ras
  4. (4S)-PROTAC SOS1 degrader-1 diTFA

(4S)-PROTAC SOS1 degrader-1 diTFA 

Cat. No.: HY-144657A Purity: 98.09%
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(4S)-PROTAC SOS1 degrader-1 (diTFA) is a potent PROTAC SOS1 degrader. (4S)-PROTAC SOS1 degrader-1 (diTFA) decreases the expression of pERK and RAS-GTP level in a dose-dependent manner. (4S)-PROTAC SOS1 degrader-1 (diTFA) significantly inhibits the tumor growth in vivo.

For research use only. We do not sell to patients.

(4S)-PROTAC SOS1 degrader-1 diTFA Chemical Structure

(4S)-PROTAC SOS1 degrader-1 diTFA Chemical Structure

Size Price Stock Quantity
1 mg USD 480 In-stock
5 mg USD 1220 In-stock
10 mg USD 1950 In-stock
25 mg USD 3900 In-stock
50 mg USD 6250 In-stock
100 mg USD 10000 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of (4S)-PROTAC SOS1 degrader-1 diTFA:

(4S)-PROTAC SOS1 degrader-1 diTFA Related Antibodies

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Description

(4S)-PROTAC SOS1 degrader-1 (diTFA) is a potent PROTAC SOS1 degrader. (4S)-PROTAC SOS1 degrader-1 (diTFA) decreases the expression of pERK and RAS-GTP level in a dose-dependent manner. (4S)-PROTAC SOS1 degrader-1 (diTFA) significantly inhibits the tumor growth in vivo[1].

Molecular Weight

1279.84

Formula

C61H78ClF7N10O8S
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@@H](C(C)(C)C)C(N1C[C@@H](O)C[C@H]1C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)CCCCCCCCN4CCN(CC4)C5=C6N=C(N7CC8(CNC8)C7)N(CC9=CC(C)=C(F)C(C)=C9)C6=CC(Cl)=C5.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (78.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7813 mL 3.9067 mL 7.8135 mL
5 mM 0.1563 mL 0.7813 mL 1.5627 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7813 mL 3.9067 mL 7.8135 mL 19.5337 mL
5 mM 0.1563 mL 0.7813 mL 1.5627 mL 3.9067 mL
10 mM 0.0781 mL 0.3907 mL 0.7813 mL 1.9534 mL
15 mM 0.0521 mL 0.2604 mL 0.5209 mL 1.3022 mL
20 mM 0.0391 mL 0.1953 mL 0.3907 mL 0.9767 mL
25 mM 0.0313 mL 0.1563 mL 0.3125 mL 0.7813 mL
30 mM 0.0260 mL 0.1302 mL 0.2604 mL 0.6511 mL
40 mM 0.0195 mL 0.0977 mL 0.1953 mL 0.4883 mL
50 mM 0.0156 mL 0.0781 mL 0.1563 mL 0.3907 mL
60 mM 0.0130 mL 0.0651 mL 0.1302 mL 0.3256 mL
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(4S)-PROTAC SOS1 degrader-1 diTFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(4S)-PROTAC SOS1 degrader-1 diTFAPROTACsRasantitumorNCI-H358 tumor xenograftsNCI-H358 cellspERKRAS-GTPKRASInhibitorinhibitorinhibit

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