4β-Hydroxycholesterol-d₅ 

4β-Hydroxycholesterol-d₅ is the deuterium labeled 4β-Hydroxycholesterol (HY-124265). 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

407.68

C₂₇H₄₁D₅O₂

17320-10-4

O[C@](C([2H])([2H])C[C@]1(C2=C([2H])C[C@@]3([C@@]1(CC[C@]4([C@]3(CC[C@@]4([C@@H](CCCC(C)C)C)[H])[H])C)[H])[H])C)([2H])[C@]2([2H])O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Granchi C,et al. 4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors. J Enzyme Inhib Med Chem. 2016;31(1):137-46.  [Content Brief]