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  4. 5,6-Dihydro-5-Fluorouracil

5,6-Dihydro-5-Fluorouracil  (Synonyms: 5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione; 5-Fluorodihydrouracil)

Cat. No.: HY-134160
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5,6-Dihydro-5-Fluorouracil (5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione) is the active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (HY-90006), which is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-Dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50=13.5 μM). Intravenous administration of 5,6-Dihydro-5-Fluorouracil (90 mg/kg/wk) in combination with 5-fluorouracil and the DPD inhibitor eniluracil (HY-10533) slows tumor growth in a rat colon cancer model.

For research use only. We do not sell to patients.

5,6-Dihydro-5-Fluorouracil Chemical Structure

5,6-Dihydro-5-Fluorouracil Chemical Structure

CAS No. : 696-06-0

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5,6-Dihydro-5-Fluorouracil Related Antibodies

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Description

5,6-Dihydro-5-Fluorouracil (5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione) is the active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (HY-90006), which is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-Dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50=13.5 μM). Intravenous administration of 5,6-Dihydro-5-Fluorouracil (90 mg/kg/wk) in combination with 5-fluorouracil and the DPD inhibitor eniluracil (HY-10533) slows tumor growth in a rat colon cancer model.

Molecular Weight

132.09

Formula

C4H5FN2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(C(F)CN1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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5,6-Dihydro-5-Fluorouracil Related Classifications

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Keywords:

5,6-Dihydro-5-Fluorouracil696-06-05-DHFU 5-Fluorodihydropyrimidine-2,4-dione 5-FluorodihydrouracilOthersInhibitorinhibitorinhibit

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