2. Anti-infection
  3. Fungal Parasite Bacterial
  4. 5,7,3',4'-Tetramethoxyflavone

5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling.

For research use only. We do not sell to patients.

5,7,3',4'-Tetramethoxyflavone Chemical Structure

5,7,3',4'-Tetramethoxyflavone Chemical Structure

CAS No. : 855-97-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

5,7,3',4'-Tetramethoxyflavone Related Antibodies

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Description

5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling[1].

IC50 & Target

Plasmodium

 

In Vitro

5,7,3',4'-Tetramethoxyflavone (5-20 μg/mL, 24 h) inhibits the expression of EP2, EP4, bcatenin and COX-2 gene in chondrocytes[1].
5,7,3',4'-Tetramethoxyflavone (5-20 μg/mL, 48 h) inhibits the protein expression of EP/cAMP/PKA signaling pathway and β-catenin signaling pathway in chondrocytes[1].
5,7,3',4'-Tetramethoxyflavone (5-20 μg/mL, 4 h) protects chondrocytes from apoptosis through regulating IRE1α[2].
5,7,3',4'-Tetramethoxyflavone (5-20 μg/mL, 4 h) reverses the expression pattern of endoplasmic reticulum (ER) stress genes due to IRE1α deficiency[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5,7,3',4'-Tetramethoxyflavone Related Antibodies

Cell Line:
Concentration:
Incubation Time:
Result:

Western Blot Analysis[2]

Cell Line: Chondrocytes
Concentration: 5-20 μg/mL
Incubation Time: 4 h
Result: Increased the protein level of Bcl-2 and XBP1s.
Decreased the expression of pro-apoptotic factors CHOP/caspase-3 and stress kinase JNK.
In Vivo

5,7,3',4'-Tetramethoxyflavone (25-100 mg/kg, i.g.) exhibits chondroprotective activity in rats[1].
5,7,3',4'-Tetramethoxyflavone (5-20 mg/kg; i.v., p.o.) has the absolute bioavailability of 14.3 % in rats[3].
1.19
Pharmacokinetic Analysis in Sprague-dawley Rats Model[3]

Route Dose (mg/kg) AUC (min μg/mL) AUC/Dose (min/mL) t1/2 (h) Tmax (h) Cmax (ng/mL) Bioavailability (%)
i.v. 5 161.49 ± 58.78 0.1154 ± 0.0420 62.85 ± 27.92 / / 14.3
p.o. 50 231.43 ± 71.87 0.0165 ± 0.0051 273.76 ± 90.23 190.34 ± 24.50 0.79 ± 0.30 /

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat knee OA model[1]
Dosage: 25-100 mg/kg
Administration: i.g.
Result: Decreased the contents of IL-1b, TNF-a, and PGE2 in a dose-dependent manner.
Decreases the expression of the inflammatory cytokines in rat knee osteoarthritis (OA) synovial fluid (SF) lavages.
Inhibited chondrocytes hypertrophy and decreased the cartilage thickness.
Exhibited down regulation of b-catenin in a dose-dependent manner.
Molecular Weight

342.35

Formula

C19H18O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C1C(OC)=CC(OC)=C3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (24.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9210 mL 14.6049 mL 29.2099 mL
5 mM 0.5842 mL 2.9210 mL 5.8420 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.15%

COA (249 KB) RP-HPLC (277 KB) LCMS (266 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9210 mL 14.6049 mL 29.2099 mL 73.0247 mL
5 mM 0.5842 mL 2.9210 mL 5.8420 mL 14.6049 mL
10 mM 0.2921 mL 1.4605 mL 2.9210 mL 7.3025 mL
15 mM 0.1947 mL 0.9737 mL 1.9473 mL 4.8683 mL
20 mM 0.1460 mL 0.7302 mL 1.4605 mL 3.6512 mL
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5,7,3',4'-Tetramethoxyflavone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5,7,3',4'-Tetramethoxyflavone855-97-0FungalParasiteBacterialChondrocytesanti-inflammatoryosteoarthritis (OA)IRE1αapoptosisanti-fungalanti-malarialanti-mycobacterialchondroprotectiveInhibitorinhibitorinhibit

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