5-Aminolevulinic acid-d₂ hydrochloride  (Synonyms: 5-ALA-d₂ hydrochloride; δ-Aminolevulinic acid-d₂ hydrochloride; 5-Amino-4-oxopentanoic acid-d₂ hydrochloride)

5-Aminolevulinic acid-d₂ (hydrochloride) is deuterium labeled 5-Aminolevulinic acid (hydrochloride).

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

169.60

C₅H₈D₂ClNO₃

187237-35-0

5451-09-2

Solid

Off-white to light yellow

OC(C([2H])([2H])CC(CN)=O)=O.Cl

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. Stummer, W., et al., Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol, 2006. 7(5): p. 392-401.  [Content Brief]

  [3]. Eyupoglu, I.Y., et al., Improving the extent of malignant glioma resection by dual intraoperative visualization approach. PLoS One, 2012. 7(9): p. e44885.  [Content Brief]