5'-Deoxy-5'-(methylthio)adenosine-d₃

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5'-Deoxy-5'-(methylthio)adenosine-d₃ is deuterium labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis.

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5'-Deoxy-5'-(methylthio)adenosine-d<sub>3</sub> Chemical Structure

5'-Deoxy-5'-(methylthio)adenosine-d₃ Chemical Structure

CAS No. : 2699607-01-5

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Other Forms of 5'-Deoxy-5'-(methylthio)adenosine-d₃:

5'-Methylthioadenosine-¹³C₆ Get quote

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Description	5'-Deoxy-5'-(methylthio)adenosine-d₃ is deuterium labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis^[1]^[2]^[3]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis.
Molecular Weight	300.35
Formula	C₁₁H₁₂D₃N₅O₃S
CAS No.	2699607-01-5
Unlabeled CAS	2457-80-9
SMILES	O[C@H]1[C@H]([C@@H](O[C@@H]1N2C3=C(N=C2)C(N)=NC=N3)CSC([2H])([2H])[2H])O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (273 KB) Handling Instructions (2659 KB)
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief] [2]. Tang Y, et al. 5'-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37(5):1366-1373. [Content Brief] [3]. Li Y, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936. [4]. Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine. Cancer Res. 2018;78(15):4386-4395. [Content Brief] [5]. Yaofeng Li, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936. [Content Brief]