5'-Methylthioadenosine-¹³C₆ (Synonyms: 5'-(Methylthio)-5'-deoxyadenosine-¹³C₆; 5'-Deoxy-5'-(methylthio)adenosine-¹³C₆; 5'-S-Methyl-5'-thioadenosine-¹³C₆)

Name: 5'-Methylthioadenosine- 13 C 6
Brand: MedChemExpress
SKU: HY-16938S
Rating: 4.5 (1 reviews)

Cat. No.: HY-16938S Purity: 98.45%: FAQs
Data Sheet SDS COA Handling Instructions

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5'-Methylthioadenosine-¹³C₆ is the ¹³C-labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].

For research use only. We do not sell to patients.

5'-Methylthioadenosine-<sup>13</sup>C<sub>6</sub> Chemical Structure

5'-Methylthioadenosine-¹³C₆ Chemical Structure

CAS No. : 2421187-73-5

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1 mg	USD 5700	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

303.29

Formula

C₅¹³C₆H₁₅N₅O₃S

CAS No.

2421187-73-5

Unlabeled CAS

2457-80-9

Appearance

Solid

Color

White to off-white

SMILES

O[13C@H]1[13C@@H](O)[13C@@]([H])(O[13C@@H]1[13CH2]S[13CH3])N2C=NC3=C2N=CN=C3N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 98.45%

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Data Sheet (269 KB) SDS (394 KB)

COA (250 KB) RP-HPLC (221 KB) MS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Yaofeng Li, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936. [Content Brief]

[2]. Tang Y, et al. 5'-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37(5):1366-1373. [Content Brief]

[3]. Li Y, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.

[4]. Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine. Cancer Res. 2018;78(15):4386-4395. [Content Brief]

[5]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5'-Methylthioadenosine-¹³C₆2421187-73-55'-(Methylthio)-5'-deoxyadenosine-¹³C₆5'-Deoxy-5'-(methylthio)adenosine-¹³C₆5'-S-Methyl-5'-thioadenosine-¹³C₆Endogenous MetaboliteApoptosisInhibitorinhibitorinhibit

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5'-Methylthioadenosine-13C6 (Synonyms: 5'-(Methylthio)-5'-deoxyadenosine-13C6; 5'-Deoxy-5'-(methylthio)adenosine-13C6; 5'-S-Methyl-5'-thioadenosine-13C6)

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5'-Methylthioadenosine-¹³C₆ (Synonyms: 5'-(Methylthio)-5'-deoxyadenosine-¹³C₆; 5'-Deoxy-5'-(methylthio)adenosine-¹³C₆; 5'-S-Methyl-5'-thioadenosine-¹³C₆)

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