5'-ODMT cEt m5U Phosphoramidite (Amidite)

Cat. No.: HY-148506 Purity: 99.25%: FAQs
Data Sheet SDS COA Handling Instructions

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5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity.

For research use only. We do not sell to patients.

5'-ODMT cEt m5U Phosphoramidite (Amidite) Chemical Structure

CAS No. : 1197033-22-9

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
10 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity^[1]^[2].

Molecular Weight

786.85

Formula

C₄₂H₅₁N₄O₉P

CAS No.

1197033-22-9

Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@]3(O[C@H]4N5C=C(C)C(NC5=O)=O)[C@@H](O[C@@]4([C@@H]3OP(N(C(C)C)C(C)C)OCCC#N)[H])C)C6=CC=CC=C6)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (158.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2709 mL	6.3545 mL	12.7089 mL
5 mM	0.2542 mL	1.2709 mL	2.5418 mL
10 mM	0.1271 mL	0.6354 mL	1.2709 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.25%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (260 KB) HNMR (300 KB) RP-HPLC (225 KB)

Handling Instructions (2659 KB)

References

[1]. Fiona J. Laraman, et al. Investigating the Activation Kinetics of Phosphoramidites for Oligonucleotide Synthesis. Org. Process Res. Dev. 2022, 26, 3, 764-772.

[2]. Vasquez G, et al. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2709 mL	6.3545 mL	12.7089 mL	31.7723 mL
	5 mM	0.2542 mL	1.2709 mL	2.5418 mL	6.3545 mL
	10 mM	0.1271 mL	0.6354 mL	1.2709 mL	3.1772 mL
	15 mM	0.0847 mL	0.4236 mL	0.8473 mL	2.1182 mL
	20 mM	0.0635 mL	0.3177 mL	0.6354 mL	1.5886 mL
	25 mM	0.0508 mL	0.2542 mL	0.5084 mL	1.2709 mL
	30 mM	0.0424 mL	0.2118 mL	0.4236 mL	1.0591 mL
	40 mM	0.0318 mL	0.1589 mL	0.3177 mL	0.7943 mL
	50 mM	0.0254 mL	0.1271 mL	0.2542 mL	0.6354 mL
	60 mM	0.0212 mL	0.1059 mL	0.2118 mL	0.5295 mL
	80 mM	0.0159 mL	0.0794 mL	0.1589 mL	0.3972 mL
	100 mM	0.0127 mL	0.0635 mL	0.1271 mL	0.3177 mL