5J-4

Cat. No.: HY-110216 Purity: 95%: FAQs
Data Sheet SDS COA Handling Instructions

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5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation.

For research use only. We do not sell to patients.

5J-4 Chemical Structure

CAS No. : 827001-82-1

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5 mg	USD 361	Ask For Quote & Lead Time
10 mg	USD 560	Ask For Quote & Lead Time

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Description

In Vivo

5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt^[1].
5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice (MOG35-55 peptide-immunized mice)^[1]
Dosage:	2 m/kg
Administration:	I.p., every alternate day for 30 days
Result:	Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population.

Molecular Weight

312.34

Formula

C₁₆H₁₂N₂O₃S

CAS No.

827001-82-1

Appearance

Powder

Color

White to off-white

SMILES

O=C(C1=CC=CO1)NC(NC2=CC=CC3=C2C=CC(O)=C3)=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 95%

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Data Sheet (270 KB) SDS (251 KB)

COA (249 KB) HNMR (67 KB) LCMS (80 KB)

Handling Instructions (2659 KB)

References

[1]. Kim KD, et al. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014 Jan 1;192(1):110-22. [Content Brief]

5J-4 Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5J-4827001-82-1CRAC ChannelCalcium release-activated channelsCa2+ release-activated Ca2+ channelsCNSexperimental autoimmune encephalomyelitismononuclear cellCD4+ cellsinflammationInhibitorinhibitorinhibit

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