(6-Isothiocyanatohexyl)(methyl)sulfane (Synonyms: Lesquerellin; 6-Methylthiohexyl isothiocyanate)

Cat. No.: HY-W714137 Purity: 96.46%: FAQs
Data Sheet SDS COA Handling Instructions

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(6-Isothiocyanatohexyl)(methyl)sulfane (Lesquerellin; 6-Methylthiohexyl isothiocyanate) is an isothiocyanate found in wasabi (W. japonica) and has various biological activities. (6-Isothiocyanatohexyl)(methyl)sulfane is active against the bacterium Bacillus subtilis and the fungus T. mentagrophytes (MIC=25 μg/mL). (6-Isothiocyanatohexyl)(methyl)sulfane also has anthelmintic activity against blue mussel (M. edulis). (6-Isothiocyanatohexyl)(methyl)sulfane has antifouling activity when applied to polyvinyl chloride (PVC) panels at a concentration of 50 μmol/cm2 in a conventional immersion test.

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(6-Isothiocyanatohexyl)(methyl)sulfane Chemical Structure

CAS No. : 4430-39-1

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
J774.1	IC₅₀	14.8 μM Compound: 2g	Growth inhibition of mouse J774.1 cells assessed as cell viability after 24 hrs by MTT assay Growth inhibition of mouse J774.1 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 19716210]
J774.1	IC₅₀	30.4 μM Compound: 2g	Antiinflammatory activity in mouse J774.1 cells assessed as inhibition of IFN-gamma and LPS-induced nitric oxide production after 20 to 24 hrs by Griess assay Antiinflammatory activity in mouse J774.1 cells assessed as inhibition of IFN-gamma and LPS-induced nitric oxide production after 20 to 24 hrs by Griess assay	[PMID: 19716210]

Molecular Weight

189.34

Formula

C₈H₁₅NS₂

CAS No.

4430-39-1

Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

CSCCCCCCN=C=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (528.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2815 mL	26.4075 mL	52.8150 mL
5 mM	1.0563 mL	5.2815 mL	10.5630 mL
10 mM	0.5282 mL	2.6408 mL	5.2815 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.46%

Select Batch:

Data Sheet (266 KB) SDS (781 KB)

COA (240 KB) HNMR (235 KB) RP-HPLC (250 KB) MS (79 KB)

Handling Instructions (2659 KB)

References

[1]. Toh, et al. ω-Methylsulfinylalkyl isothiocyanates in wasabi, Wasabia japonica Matsum. Agric. Biol. Chem. 54(6), 1587-1589 (1990).

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.2815 mL	26.4075 mL	52.8150 mL	132.0376 mL
	5 mM	1.0563 mL	5.2815 mL	10.5630 mL	26.4075 mL
	10 mM	0.5282 mL	2.6408 mL	5.2815 mL	13.2038 mL
	15 mM	0.3521 mL	1.7605 mL	3.5210 mL	8.8025 mL
	20 mM	0.2641 mL	1.3204 mL	2.6408 mL	6.6019 mL
	25 mM	0.2113 mL	1.0563 mL	2.1126 mL	5.2815 mL
	30 mM	0.1761 mL	0.8803 mL	1.7605 mL	4.4013 mL
	40 mM	0.1320 mL	0.6602 mL	1.3204 mL	3.3009 mL
	50 mM	0.1056 mL	0.5282 mL	1.0563 mL	2.6408 mL
	60 mM	0.0880 mL	0.4401 mL	0.8803 mL	2.2006 mL
	80 mM	0.0660 mL	0.3301 mL	0.6602 mL	1.6505 mL
	100 mM	0.0528 mL	0.2641 mL	0.5282 mL	1.3204 mL

(6-Isothiocyanatohexyl)(methyl)sulfane Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(6-Isothiocyanatohexyl)(methyl)sulfane4430-39-1Lesquerellin 6-Methylthiohexyl isothiocyanateBacterialInhibitorinhibitorinhibit

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