2. PROTAC
  3. PROTAC Linkers
  4. 6-Maleimidocaproic acid sulfo-NHS sodium

6-Maleimidocaproic acid sulfo-NHS sodium  (Synonyms: Sulfo-EMCS)

Cat. No.: HY-136158A Purity: 98.91%
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6-Maleimidocaproic acid sulfo-NHS (Sulfo-EMCS) sodium is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

6-Maleimidocaproic acid sulfo-NHS sodium Chemical Structure

6-Maleimidocaproic acid sulfo-NHS sodium Chemical Structure

CAS No. : 215312-86-0

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10 mg USD 50 In-stock
25 mg USD 100 In-stock
50 mg USD 150 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 6-Maleimidocaproic acid sulfo-NHS sodium:

6-Maleimidocaproic acid sulfo-NHS sodium Related Antibodies

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Description

6-Maleimidocaproic acid sulfo-NHS (Sulfo-EMCS) sodium is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6-Maleimidocaproic acid sulfo-NHS sodium Related Antibodies
Molecular Weight

410.33

Formula

C14H15N2NaO9S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(ON1C(C(S(=O)(O[Na])=O)CC1=O)=O)CCCCCN2C(C=CC2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (304.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4371 mL 12.1853 mL 24.3706 mL
5 mM 0.4874 mL 2.4371 mL 4.8741 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4371 mL 12.1853 mL 24.3706 mL 60.9266 mL
5 mM 0.4874 mL 2.4371 mL 4.8741 mL 12.1853 mL
10 mM 0.2437 mL 1.2185 mL 2.4371 mL 6.0927 mL
15 mM 0.1625 mL 0.8124 mL 1.6247 mL 4.0618 mL
20 mM 0.1219 mL 0.6093 mL 1.2185 mL 3.0463 mL
25 mM 0.0975 mL 0.4874 mL 0.9748 mL 2.4371 mL
30 mM 0.0812 mL 0.4062 mL 0.8124 mL 2.0309 mL
40 mM 0.0609 mL 0.3046 mL 0.6093 mL 1.5232 mL
50 mM 0.0487 mL 0.2437 mL 0.4874 mL 1.2185 mL
60 mM 0.0406 mL 0.2031 mL 0.4062 mL 1.0154 mL
80 mM 0.0305 mL 0.1523 mL 0.3046 mL 0.7616 mL
100 mM 0.0244 mL 0.1219 mL 0.2437 mL 0.6093 mL
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6-Maleimidocaproic acid sulfo-NHS sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Maleimidocaproic acid sulfo-NHS215312-86-0Sulfo-EMCSPROTAC LinkersInhibitorinhibitorinhibit

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