2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. ROR
  4. 7ß,27-Dihydroxycholesterol

7ß,27-Dihydroxycholesterol  (Synonyms: 7β, 27-OHC)

Cat. No.: HY-138115 Purity: ≥99.0%
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7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1.

For research use only. We do not sell to patients.

7ß,27-Dihydroxycholesterol Chemical Structure

7ß,27-Dihydroxycholesterol Chemical Structure

CAS No. : 240129-43-5

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Based on 1 publication(s) in Google Scholar

7ß,27-Dihydroxycholesterol Related Antibodies

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Description

7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1[1].

IC50 & Target[1]

RORγt

120 nM (Ki)

In Vitro

7ß,27-Dihydroxycholesterol (0.3 μM or 6 μM; 2 h) induces IL-17 production in human and mouse Th17 cells, respectively, in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

7ß,27-Dihydroxycholesterol Related Antibodies
In Vivo

7ß,27-Dihydroxycholesterol (60 mg/kg; s.c.; twice daily for 3 d) induces IL-17 production in mice in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

418.65

Formula

C27H46O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@H](CO)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : ≥ 20 mg/mL (47.77 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3886 mL 11.9432 mL 23.8863 mL
5 mM 0.4777 mL 2.3886 mL 4.7773 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (252 KB)

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.3886 mL 11.9432 mL 23.8863 mL 59.7158 mL
5 mM 0.4777 mL 2.3886 mL 4.7773 mL 11.9432 mL
10 mM 0.2389 mL 1.1943 mL 2.3886 mL 5.9716 mL
15 mM 0.1592 mL 0.7962 mL 1.5924 mL 3.9811 mL
20 mM 0.1194 mL 0.5972 mL 1.1943 mL 2.9858 mL
25 mM 0.0955 mL 0.4777 mL 0.9555 mL 2.3886 mL
30 mM 0.0796 mL 0.3981 mL 0.7962 mL 1.9905 mL
40 mM 0.0597 mL 0.2986 mL 0.5972 mL 1.4929 mL
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7ß,27-Dihydroxycholesterol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7ß,27-Dihydroxycholesterol240129-43-57β, 27-OHCRORRAR-related orphan receptorInhibitorinhibitorinhibit

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