7,3',4'-Trihydroxy-3-benzyl-2H-chromene

Name: 7,3',4'-Trihydroxy-3-benzyl-2H-chromene
Brand: MedChemExpress
SKU: HY-N2735
Rating: 4.5 (1 reviews)

Cat. No.: HY-N2735 Purity: 95.47%: FAQs
Data Sheet SDS COA Handling Instructions

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7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC₅₀ values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus.

For research use only. We do not sell to patients.

7,3',4'-Trihydroxy-3-benzyl-2H-chromene Chemical Structure

CAS No. : 1111897-60-9

Size	Price	Stock	Quantity
1 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC50: 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5 µM [H9N2]^[1].

In Vitro

7,3',4'-Trihydroxy-3-benzyl-2H-chromene (Compound 11) has potent NAs inhibitory activities with IC₅₀ values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5 µM [H9N2], respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

270.28

Formula

C₁₆H₁₄O₄

CAS No.

1111897-60-9

Appearance

Solid

Color

Brown to black

SMILES

OC1=CC=C(C(OC2)=C1)C=C2CC3=CC(O)=C(O)C=C3

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (369.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6999 mL	18.4993 mL	36.9987 mL
5 mM	0.7400 mL	3.6999 mL	7.3997 mL
10 mM	0.3700 mL	1.8499 mL	3.6999 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.47%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (246 KB) HNMR (223 KB) LCMS (86 KB)

Handling Instructions (2659 KB)

References

[1]. Hyung Jae Jeong, et al. Homoisoflavonoids from Caesalpinia sappan displaying viral neuraminidases inhibition. Biol Pharm Bull. 2012;35(5):786-90. [Content Brief]

[2]. Huanxin Zhao, et al. A new homoisoflavan from Caesalpinia sappan. J Nat Med. 2008 Jul;62(3):325-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6999 mL	18.4993 mL	36.9987 mL	92.4967 mL
	5 mM	0.7400 mL	3.6999 mL	7.3997 mL	18.4993 mL
	10 mM	0.3700 mL	1.8499 mL	3.6999 mL	9.2497 mL
	15 mM	0.2467 mL	1.2333 mL	2.4666 mL	6.1664 mL
	20 mM	0.1850 mL	0.9250 mL	1.8499 mL	4.6248 mL
	25 mM	0.1480 mL	0.7400 mL	1.4799 mL	3.6999 mL
	30 mM	0.1233 mL	0.6166 mL	1.2333 mL	3.0832 mL
	40 mM	0.0925 mL	0.4625 mL	0.9250 mL	2.3124 mL
	50 mM	0.0740 mL	0.3700 mL	0.7400 mL	1.8499 mL
	60 mM	0.0617 mL	0.3083 mL	0.6166 mL	1.5416 mL
	80 mM	0.0462 mL	0.2312 mL	0.4625 mL	1.1562 mL
	100 mM	0.0370 mL	0.1850 mL	0.3700 mL	0.9250 mL