2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. 7-Hydroxy-4-methyl-2(1H)-quinolone

7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b) is a fluorescent hydroxylated product. 7-Hydroxy-4-methyl-2(1H)-quinolone can be used for detecting hydroxyl radicals of DNA damage.

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7-Hydroxy-4-methyl-2(1H)-quinolone Chemical Structure

7-Hydroxy-4-methyl-2(1H)-quinolone Chemical Structure

CAS No. : 20513-71-7

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7-Hydroxy-4-methyl-2(1H)-quinolone Related Antibodies

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Description

7-Hydroxy-4-methyl-2(1H)-quinolone (compound 2b) is a fluorescent hydroxylated product. 7-Hydroxy-4-methyl-2(1H)-quinolone can be used for detecting hydroxyl radicals of DNA damage[1].

Cellular Effect
Cell Line Type Value Description References
U-937 CC50
> 1000 μM
Compound: 13
Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay
Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay
[PMID: 22925447]
U-937 IC50
258.7 μM
Compound: 13
Antiproliferative activity against human U937 cells assessed as incorporation of [3H]-methyl-thymidine after 12 hrs by scintillation counting
Antiproliferative activity against human U937 cells assessed as incorporation of [3H]-methyl-thymidine after 12 hrs by scintillation counting
[PMID: 22925447]
Molecular Weight

175.18

Formula

C10H9NO2
CAS No.
SMILES

O=C1NC2=C(C=CC(O)=C2)C(C)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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7-Hydroxy-4-methyl-2(1H)-quinolone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Hydroxy-4-methyl-2(1H)-quinolone20513-71-7Reactive Oxygen SpeciesHydroxylatedhydroxyl radicalsDNA damageInhibitorinhibitorinhibit

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