2. PI3K/Akt/mTOR TGF-beta/Smad Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. Akt PKC CDK Apoptosis
  4. 7-Hydroxystaurosporine

7-Hydroxystaurosporine  (Synonyms: UCN-01; KRX-0601)

Cat. No.: HY-13661
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7-Hydroxystaurosporine (UCN-01) is a synthetic derivative of Staurosporine (HY-15141) with antitumor activity. 7-hydroxystaurosporine inhibits serine/threonine kinase AKT and calcium-dependent protein kinase C activity. 7-hydroxystaurosporine also activates indirectly cyclin-dependent kinases (CDKs). 7-hydroxystaurosporine arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis.

For research use only. We do not sell to patients.

7-Hydroxystaurosporine Chemical Structure

7-Hydroxystaurosporine Chemical Structure

CAS No. : 112953-11-4

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7-Hydroxystaurosporine Related Antibodies

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Akt Akt1 Akt2 Akt3

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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Description

7-Hydroxystaurosporine (UCN-01) is a synthetic derivative of Staurosporine (HY-15141) with antitumor activity. 7-hydroxystaurosporine inhibits serine/threonine kinase AKT and calcium-dependent protein kinase C activity. 7-hydroxystaurosporine also activates indirectly cyclin-dependent kinases (CDKs). 7-hydroxystaurosporine arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis[1][2].

Molecular Weight

482.53

Formula

C28H26N4O4
CAS No.
SMILES

C[C@]12N3C4=C(C5=CC=CC=C53)C([C@H](NC6=O)O)=C6C7=C4N([C@](C[C@H]([C@H]2OC)NC)([H])O1)C8=CC=CC=C78
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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7-Hydroxystaurosporine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Hydroxystaurosporine112953-11-4UCN-01 KRX-0601UCN01UCN 01KRX0601KRX 0601KRX-0601AktPKCCDKApoptosisPKBProtein kinase BProtein kinase CCyclin dependent kinaseantitumor activityAKTprotein kinase CCDKstumor cellsnucleotide excision repairapoptosisInhibitorinhibitorinhibit

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