2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Nucleoside Antimetabolite/Analog Endogenous Metabolite
  4. 7-Methylguanosine-d3

7-Methylguanosine-d3 is the deuterium labeled 7-Methylguanosine[1]. 7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8 ± 7.5 μM[2].

For research use only. We do not sell to patients.

7-Methylguanosine-d<sub>3</sub> Chemical Structure

7-Methylguanosine-d3 Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of 7-Methylguanosine-d3:

7-Methylguanosine-d3 Related Antibodies

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  • Purity & Documentation

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Description

7-Methylguanosine-d3 is the deuterium labeled 7-Methylguanosine[1]. 7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8 ± 7.5 μM[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

7-Methylguanosine-d3 Related Antibodies
Molecular Weight

301.29

Formula

C11H13D3N5O5
Unlabeled CAS

20244-86-4
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3[N](C([2H])([2H])[2H])=C2)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (82.98 mM; ultrasonic and warming and heat to 60°C)

H2O : 25 mg/mL (82.98 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3191 mL 16.5953 mL 33.1906 mL
5 mM 0.6638 mL 3.3191 mL 6.6381 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O 1 mM 3.3191 mL 16.5953 mL 33.1906 mL 82.9765 mL
5 mM 0.6638 mL 3.3191 mL 6.6381 mL 16.5953 mL
10 mM 0.3319 mL 1.6595 mL 3.3191 mL 8.2977 mL
15 mM 0.2213 mL 1.1064 mL 2.2127 mL 5.5318 mL
20 mM 0.1660 mL 0.8298 mL 1.6595 mL 4.1488 mL
25 mM 0.1328 mL 0.6638 mL 1.3276 mL 3.3191 mL
30 mM 0.1106 mL 0.5532 mL 1.1064 mL 2.7659 mL
40 mM 0.0830 mL 0.4149 mL 0.8298 mL 2.0744 mL
50 mM 0.0664 mL 0.3319 mL 0.6638 mL 1.6595 mL
60 mM 0.0553 mL 0.2766 mL 0.5532 mL 1.3829 mL
80 mM 0.0415 mL 0.2074 mL 0.4149 mL 1.0372 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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7-Methylguanosine-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Methylguanosine-d3Nucleoside Antimetabolite/AnalogEndogenous MetaboliteInhibitorinhibitorinhibit

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