2. Isotope-Labeled Compounds
  3. Isotope-Labeled Nucleic Acids

Isotope-Labeled Nucleic Acids

Nucleic acids, comprising of nucleobases, nucleosides, and nucleotides, are biopolymers, macromolecules, essential to all known forms of life. The two main classes of nucleic acids are deoxyribonucleic acid ( DNA ) and ribonucleic acid ( RNA ), both of which serve as the genetic information-carrying molecules. MedChemExpress ( MCE ) offers various Stable Isotope-Labeled nucleic acids and derivatives to assist protein structural analysis and DNA/RNA related researches.

Isotope-Labeled Nucleic Acids (63):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0152S1
    Adenine-13C 86967-48-8 99.75%
    Adenine-13C is the 13C labeled Adenine[1]. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[2][3][4].
    Adenine-<sup>13</sup>C
  • HY-B1449S
    Uridine-15N2 92487-68-8 98.00%
    Uridine-15N2 is the 15N labeled Uridine[1].
    Uridine-<sup>15</sup>N<sub>2</sub>
  • HY-150792S
    Inosine-15N4 204634-01-5 98.4%
    Inosine-15N4 is the 15N labeled Inosine[1].
    Inosine-<sup>15</sup>N<sub>4</sub>
  • HY-D0184S2
    2'-Deoxycytidine-15N3 99.70%
    2'-Deoxycytidine-15N3 is the 15N labeled 2'-Deoxycytidine[1]. 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu)[2].
    2'-Deoxycytidine-<sup>15</sup>N<sub>3</sub>
  • HY-I0960S1
    Uracil-13C4 98.00%
    Uracil-13C4 is the 13C labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
    Uracil-<sup>13</sup>C<sub>4</sub>
  • HY-I0960S3
    Uracil-13C4,15N2 202407-06-5 ≥98.0%
    Uracil-13C4,15N2 is the 13C and 15N labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
    Uracil-<sup>13</sup>C<sub>4</sub>,<sup>15</sup>N<sub>2</sub>
  • HY-B1511S
    Cyclic AMP-13C5 2170095-23-3
    Cyclic AMP-13C5 is a deuterated cyclic AMP.
    Cyclic AMP-<sup>13</sup>C<sub>5</sub>
  • HY-A0181S
    Adenosine monophosphate-13C10,15N5 ≥99.0%
    Adenosine monophosphate-13C10,15N5 is the 13C-labeled and 15N-labeled Adenosine monophosphate. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction[1].
    Adenosine monophosphate-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>5</sub>
  • HY-D0185S4
    2'-Deoxyguanosine-13C10,15N5 monohydrate 2483830-26-6 99.80%
    2'-Deoxyguanosine-13C10,15N5 (monohydrate) is the 13C and 15N labeled 2'-Deoxyguanosine monohydrate[1]. 2'-Deoxyguanosine monohydrate is an endogenous metabolite.
    2'-Deoxyguanosine-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>5</sub> monohydrate
  • HY-N0091S7
    Hypoxanthine-15N4 77910-30-6 98.5%
    Hypoxanthine-15N4 is the 15N labeled Hypoxanthine[1]. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia[2].
    Hypoxanthine-<sup>15</sup>N<sub>4</sub>
  • HY-N1150S9
    Thymidine-15N2 ≥99.0%
    Thymidine-15N2 is the 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].
    Thymidine-<sup>15</sup>N<sub>2</sub>
  • HY-W011540S
    8-Hydroxy-2'-deoxyguanosine-15N5 569649-11-2 ≥99.0%
    8-Hydroxy-2'-deoxyguanosine-15N5 is the 15N labeled 8-Hydroxy-2'-deoxyguanosine[1]. 8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis[2].
    8-Hydroxy-2'-deoxyguanosine-<sup>15</sup>N<sub>5</sub>
  • HY-D0186S7
    2'-Deoxyuridine-13C,15N2 369656-76-8 98.08%
    2'-Deoxyuridine-13C,15N2 is the 13C and 15N labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].
    2'-Deoxyuridine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-N0097S3
    Guanosine-15N5 99.60%
    Guanosine-15N5 is the 15N labeled Guanosine[1]. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity[2].
    Guanosine-<sup>15</sup>N<sub>5</sub>
  • HY-107372S
    Uridine triphosphate-13C9,15N2 sodium 285978-18-9
    Uridine triphosphate-13C9,15N2 (sodium) is a labeled Uridine triphosphate sodium. Uridine triphosphate sodium can be used in nucleic acid synthesis.
    Uridine triphosphate-<sup>13</sup>C<sub>9</sub>,<sup>15</sup>N<sub>2</sub> sodium
  • HY-I0960S
    Uracil-13C2,15N2 181517-11-3
    Uracil-13C2,15N2 is the 13C-labeled and 15N-labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.
    Uracil-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N<sub>2</sub>
  • HY-150843S
    Adenosine 5'-triphosphate-15N5 ammonium ≥98.0%
    Adenosine 5'-triphosphate-15N5 (ammonium) is the 15N labeled Adenosine 5'-triphosphate ammonium[1].
    Adenosine 5'-triphosphate-<sup>15</sup>N<sub>5</sub> ammonium
  • HY-13677S1
    6-Mercaptopurine-13C2,15N 1190008-04-8
    6-Mercaptopurine-13C2,15N is the 13C- and 15N-labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.
    6-Mercaptopurine-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N
  • HY-N1150S8
    Thymidine-13C10,15N2 1821188-00-4 99.90%
    Thymidine-13C10,15N2 is the 13C and 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].
    Thymidine-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>2</sub>
  • HY-113225S3
    Guanosine triphosphate-15N5 dilithium
    Guanosine triphosphate-15N5 (GTP-15N5) dilithium is 15N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
    Guanosine triphosphate-<sup>15</sup>N<sub>5</sub> dilithium