2. Isotope-Labeled Compounds
  3. Isotope-Labeled Nucleic Acids

Isotope-Labeled Nucleic Acids

Nucleic acids, comprising of nucleobases, nucleosides, and nucleotides, are biopolymers, macromolecules, essential to all known forms of life. The two main classes of nucleic acids are deoxyribonucleic acid ( DNA ) and ribonucleic acid ( RNA ), both of which serve as the genetic information-carrying molecules. MedChemExpress ( MCE ) offers various Stable Isotope-Labeled nucleic acids and derivatives to assist protein structural analysis and DNA/RNA related researches.

Isotope-Labeled Nucleic Acids (125):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0617S
    S-Adenosyl-L-methionine-d3 68684-40-2 98.05%
    S-Adenosyl-L-methionine-d3 is the deuterated product of S-Adenosyl-L-methionine. S-Adenosyl-L-methionine is endogenously produced from methionine and ATP through the action of methionine adenosyltransferase and is an important orally active methyl donor.
    S-Adenosyl-L-methionine-d<sub>3</sub>
  • HY-19528S
    SAH-d4 ≥99.0%
    SAH-d4 is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].
    SAH-d<sub>4</sub>
  • HY-B0152S1
    Adenine-13C 86967-48-8 99.75%
    Adenine-13C is the 13C labeled Adenine[1]. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[2][3][4].
    Adenine-<sup>13</sup>C
  • HY-F0004S
    β-Nicotinamide mononucleotide-d4 99.55%
    β-Nicotinamide mononucleotide-d4 is the deuterium labeled β-Nicotinamide mononucleotide. β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity[1].
    β-Nicotinamide mononucleotide-d<sub>4</sub>
  • HY-N1150S1
    Thymidine-d4 347841-67-2 ≥99.0%
    Thymidine-d4 is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1][2][3].
    Thymidine-d<sub>4</sub>
  • HY-16938S1
    5'-Methylthioadenosine-d3 174838-38-1 99.81%
    5'-Methylthioadenosine-d3 is the deuterium labeled 5'-Methylthioadenosine[1]. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2][3][4].
    5'-Methylthioadenosine-d<sub>3</sub>
  • HY-I0960S1
    Uracil-13C4 98.00%
    Uracil-13C4 is the 13C labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
    Uracil-<sup>13</sup>C<sub>4</sub>
  • HY-B0152S
    Adenine-d 109923-52-6 ≥99.0%
    Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].
    Adenine-d
  • HY-19312S
    3-Methyladenine-d3 110953-39-4 99.44%
    3-Methyladenine-d3 is the deuterium labeled 3-Methyladenine[1]. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K[2].
    3-Methyladenine-d<sub>3</sub>
  • HY-122524S
    7-Methylguanosine-d3 98.54%
    7-Methylguanosine-d3 is the deuterium labeled 7-Methylguanosine[1]. 7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8 ± 7.5 μM[2].
    7-Methylguanosine-d<sub>3</sub>
  • HY-B1743S
    Puromycin-d3 98.96%
    Puromycin-d3 is the deuterium labeled Puromycin. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.
    Puromycin-d<sub>3</sub>
  • HY-113139S
    1-Methylinosine-d3 ≥99.0%
    1-Methylinosine-d3 is the deuterium labeled 1-Methylinosine. 1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA[1].
    1-Methylinosine-d<sub>3</sub>
  • HY-B0228S
    Adenosine-d 109923-50-4 99.72%
    Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1][2].
    Adenosine-d
  • HY-150792S
    Inosine-15N4 204634-01-5 98.4%
    Inosine-15N4 is the 15N labeled Inosine[1].
    Inosine-<sup>15</sup>N<sub>4</sub>
  • HY-D0185S4
    2'-Deoxyguanosine-13C10,15N5 monohydrate 2483830-26-6 99.80%
    2'-Deoxyguanosine-13C10,15N5 (monohydrate) is the 13C and 15N labeled 2'-Deoxyguanosine monohydrate[1]. 2'-Deoxyguanosine monohydrate is an endogenous metabolite.
    2'-Deoxyguanosine-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>5</sub> monohydrate
  • HY-B1449S
    Uridine-15N2 92487-68-8 98.00%
    Uridine-15N2 is the 15N labeled Uridine[1].
    Uridine-<sup>15</sup>N<sub>2</sub>
  • HY-D0184S2
    2'-Deoxycytidine-15N3 99.70%
    2'-Deoxycytidine-15N3 is the 15N labeled 2'-Deoxycytidine[1]. 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu)[2].
    2'-Deoxycytidine-<sup>15</sup>N<sub>3</sub>
  • HY-N0091S7
    Hypoxanthine-15N4 77910-30-6 98.5%
    Hypoxanthine-15N4 is the 15N labeled Hypoxanthine[1]. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia[2].
    Hypoxanthine-<sup>15</sup>N<sub>4</sub>
  • HY-N1150S9
    Thymidine-15N2 ≥99.0%
    Thymidine-15N2 is the 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].
    Thymidine-<sup>15</sup>N<sub>2</sub>
  • HY-W011540S
    8-Hydroxy-2'-deoxyguanosine-15N5 569649-11-2 ≥99.0%
    8-Hydroxy-2'-deoxyguanosine-15N5 is the 15N labeled 8-Hydroxy-2'-deoxyguanosine[1]. 8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis[2].
    8-Hydroxy-2'-deoxyguanosine-<sup>15</sup>N<sub>5</sub>