8-Hydroxyguanine

Name: 8-Hydroxyguanine
Brand: MedChemExpress
SKU: HY-113338
Rating: 4.5 (1 reviews)

Cat. No.: HY-113338 Purity: 98.37%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species. It causes G-T and A-C substitutions.

For research use only. We do not sell to patients.

8-Hydroxyguanine Chemical Structure

CAS No. : 5614-64-2

Size	Price	Stock	Quantity
5 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 304	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 8-Hydroxyguanine:

8-Hydroxyguanine hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species. It causes G-T and A-C substitutions.

IC₅₀ & Target

Human Endogenous Metabolite

Molecular Weight

167.13

Formula

C₅H₅N₅O₂

CAS No.

5614-64-2

Appearance

Solid

Color

Light brown to khaki

SMILES

O=C1NC(N)=NC2=C1NC(N2)=O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

1M NaOH : 25 mg/mL (149.58 mM; ultrasonic and adjust pH to 12 with 1M NaOH)

H₂O : 4.72 mg/mL (28.24 mM; ultrasonic and warming and adjust pH to 11 with NaOH and heat to 60°C)

Ethanol : < 1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*8-Hydroxyguanine is usually formulated as a suspension.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.9834 mL	29.9168 mL	59.8337 mL
5 mM	1.1967 mL	5.9834 mL	11.9667 mL
10 mM	0.5983 mL	2.9917 mL	5.9834 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.37%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (247 KB) HNMR (251 KB) RP-HPLC (246 KB)

Handling Instructions (2659 KB)

References

[1]. Arai T, et al. High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress. Carcinogenesis. 2002 Dec;23(12):2005-10. [Content Brief]

[2]. Floyd RA, et al. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis. 1990 Sep;11(9):1447-50. [Content Brief]

[3]. Cheng KC, et al. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. J Biol Chem. 1992 Jan 5;267(1):166-72. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / 1M NaOH	1 mM	5.9834 mL	29.9168 mL	59.8337 mL	149.5842 mL
	5 mM	1.1967 mL	5.9834 mL	11.9667 mL	29.9168 mL
	10 mM	0.5983 mL	2.9917 mL	5.9834 mL	14.9584 mL
	15 mM	0.3989 mL	1.9945 mL	3.9889 mL	9.9723 mL
	20 mM	0.2992 mL	1.4958 mL	2.9917 mL	7.4792 mL
	25 mM	0.2393 mL	1.1967 mL	2.3933 mL	5.9834 mL
1M NaOH	30 mM	0.1994 mL	0.9972 mL	1.9945 mL	4.9861 mL
	40 mM	0.1496 mL	0.7479 mL	1.4958 mL	3.7396 mL
	50 mM	0.1197 mL	0.5983 mL	1.1967 mL	2.9917 mL
	60 mM	0.0997 mL	0.4986 mL	0.9972 mL	2.4931 mL
	80 mM	0.0748 mL	0.3740 mL	0.7479 mL	1.8698 mL
	100 mM	0.0598 mL	0.2992 mL	0.5983 mL	1.4958 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.