8-Isoprostaglandin F2α-¹³C₅

Cat. No.: HY-113209S2: FAQs
Data Sheet Handling Instructions

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8-Isoprostaglandin F2α-¹³C₅ is ¹³C labeled 8-Isoprostaglandin F2α (HY-113209). 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.

For research use only. We do not sell to patients.

8-Isoprostaglandin F2α-<sup>13</sup>C<sub>5</sub> Chemical Structure

8-Isoprostaglandin F2α-¹³C₅ Chemical Structure

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Other Forms of 8-Isoprostaglandin F2α-¹³C₅:

8-Isoprostaglandin F2α Get quote
ent-8-Iso-15(S)-prostaglandin F2α Get quote
8-Iso-PGF2a-d₄ Get quote
8-iso Prostaglandin F2α-d₉ Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

352.39

Formula

C₁₅¹³C₅H₂₇O₅

Unlabeled CAS

27415-26-5

SMILES

CCCCC[C@H](O)/C=C/[C@@H]1[C@@H]([C@@H](O)C[C@H]1O)C/C=[13C]\[13C][13C][13C][13C](O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (283.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8378 mL	14.1888 mL	28.3776 mL
5 mM	0.5676 mL	2.8378 mL	5.6755 mL
10 mM	0.2838 mL	1.4189 mL	2.8378 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8378 mL	14.1888 mL	28.3776 mL	70.9441 mL
	5 mM	0.5676 mL	2.8378 mL	5.6755 mL	14.1888 mL
	10 mM	0.2838 mL	1.4189 mL	2.8378 mL	7.0944 mL
	15 mM	0.1892 mL	0.9459 mL	1.8918 mL	4.7296 mL
	20 mM	0.1419 mL	0.7094 mL	1.4189 mL	3.5472 mL
	25 mM	0.1135 mL	0.5676 mL	1.1351 mL	2.8378 mL
	30 mM	0.0946 mL	0.4730 mL	0.9459 mL	2.3648 mL
	40 mM	0.0709 mL	0.3547 mL	0.7094 mL	1.7736 mL
	50 mM	0.0568 mL	0.2838 mL	0.5676 mL	1.4189 mL
	60 mM	0.0473 mL	0.2365 mL	0.4730 mL	1.1824 mL
	80 mM	0.0355 mL	0.1774 mL	0.3547 mL	0.8868 mL
	100 mM	0.0284 mL	0.1419 mL	0.2838 mL	0.7094 mL