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  4. 9,10-Anthracenediyl-bis(methylene)dimalonic acid

9,10-Anthracenediyl-bis(methylene)dimalonic acid  (Synonyms: ABMDMA)

Cat. No.: HY-D0034 Purity: 97.03%
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9,10-Anthracenediyl-bis(methylene)dimalonic acid (ABMDMA) is a biological dye and indicator used to detect singlet oxygen generation (SOG). 9,10-Anthracenediyl-bis(methylene)dimalonic acid is water-soluble derivative of anthracene. 9,10-Anthracenediyl-bis(methylene)dimalonic acid can be photobleached by singlet oxygen to its corresponding endoperoxide. This reaction can be monitored spectrophotometrically by recording the decrease of absorbance at 400 nm.

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9,10-Anthracenediyl-bis(methylene)dimalonic acid Chemical Structure

9,10-Anthracenediyl-bis(methylene)dimalonic acid Chemical Structure

CAS No. : 307554-62-7

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9,10-Anthracenediyl-bis(methylene)dimalonic acid Related Antibodies

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1 Publications Citing Use of MCE 9,10-Anthracenediyl-bis(methylene)dimalonic acid

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Description

9,10-Anthracenediyl-bis(methylene)dimalonic acid (ABMDMA) is a biological dye and indicator used to detect singlet oxygen generation (SOG). 9,10-Anthracenediyl-bis(methylene)dimalonic acid is water-soluble derivative of anthracene. 9,10-Anthracenediyl-bis(methylene)dimalonic acid can be photobleached by singlet oxygen to its corresponding endoperoxide. This reaction can be monitored spectrophotometrically by recording the decrease of absorbance at 400 nm[1][2].

In Vitro

Preparation of 9,10-Anthracenediyl-bis(methylene)dimalonic acid Staining Working Solution:[3]
0.15 mM of the sodium salt of 9,10-Anthracenediyl-bis(methylene)dimalonic acid in water was mixed with Pc4SNP or Pc4 to give a final concentration of 2 μM.
Detection of singlet oxygen generation:[1]
In a typical procedure, 0.5 mL of 9,10-Anthracenediyl-bis(methylene)dimalonic acid water solution (0.07 mg/mL) was added to methylene blue (MB)-GO or MB water solutions both containing 3.6 μg/mL (MB/H2O) to give the final 9,10-Anthracenediyl-bis(methylene)dimalonic acid concentration of 3.33 μg/mL. Next, 1 mL of MB-GO/9,10-Anthracenediyl-bis(methylene)dimalonic acid or MB/9,10-Anthracenediyl-bis(methylene)dimalonic acid solutions were poured into open quartz cuvettes and irradiated with a 785 nm laser for 55 min. The reactions were monitored with UV-vis spectroscopy by recording an absorbance decrease at 400 nm (λmax 9,10-Anthracenediyl-bis(methylene)dimalonic acid) at 5-min intervals.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9,10-Anthracenediyl-bis(methylene)dimalonic acid Related Antibodies
Molecular Weight

410.37

Formula

C22H18O8
CAS No.
Appearance

Solid

Color

Light yellow to yellow

Emission (Em)

407
Excitation (Ex)

380
SMILES

OC(C(C(O)=O)CC1=C(C=CC=C2)C2=C(CC(C(O)=O)C(O)=O)C3=C1C=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (243.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4368 mL 12.1841 mL 24.3683 mL
5 mM 0.4874 mL 2.4368 mL 4.8737 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.03%

COA (254 KB) HNMR (114 KB) RP-HPLC (427 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4368 mL 12.1841 mL 24.3683 mL 60.9206 mL
5 mM 0.4874 mL 2.4368 mL 4.8737 mL 12.1841 mL
10 mM 0.2437 mL 1.2184 mL 2.4368 mL 6.0921 mL
15 mM 0.1625 mL 0.8123 mL 1.6246 mL 4.0614 mL
20 mM 0.1218 mL 0.6092 mL 1.2184 mL 3.0460 mL
25 mM 0.0975 mL 0.4874 mL 0.9747 mL 2.4368 mL
30 mM 0.0812 mL 0.4061 mL 0.8123 mL 2.0307 mL
40 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.5230 mL
50 mM 0.0487 mL 0.2437 mL 0.4874 mL 1.2184 mL
60 mM 0.0406 mL 0.2031 mL 0.4061 mL 1.0153 mL
80 mM 0.0305 mL 0.1523 mL 0.3046 mL 0.7615 mL
100 mM 0.0244 mL 0.1218 mL 0.2437 mL 0.6092 mL
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9,10-Anthracenediyl-bis(methylene)dimalonic acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

9,10-Anthracenediyl-bis(methylene)dimalonic acid307554-62-7ABMDMAFluorescent DyeSinglet OxygenSOGABDAphotobleachingInhibitorinhibitorinhibit

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