AFP464 free base (Synonyms: NSC710464 free base)

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AFP464 free base (NSC710464 free base), is an active HIF-1α inhibitor with an IC₅₀ of 0.25 μM, also is a potent aryl hydrocarbon receptor (AhR) activator.

For research use only. We do not sell to patients.

AFP464 free base Chemical Structure

CAS No. : 468719-52-0

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Other Forms of AFP464 free base:

AFP464 dihydrochloride Get quote

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HIF-1α HIF

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Purity & Documentation
References
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Description

AFP464 free base (NSC710464 free base), is an active HIF-1α inhibitor with an IC₅₀ of 0.25 μM, also is a potent aryl hydrocarbon receptor (AhR) activator.

IC₅₀ & Target

IC50：0.25 μM (HIF-1α)^[1]

Clinical Trial

Molecular Weight

448.44

Formula

C₂₂H₂₃F₃N₄O₃

CAS No.

468719-52-0

SMILES

O=C(NC1=CC=C(C2=CC(C3=C(N)C(F)=C(C)C(F)=C3O2)=O)C=C1F)[C@@H](N)CCCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Terzuoli E1, Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res. 2010 Sep 1;70(17):6837-48. [Content Brief]

AFP464 free base Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AFP464468719-52-0NSC710464AFP 464AFP-464NSC 710464NSC-710464HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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