2. GPCR/G Protein
  3. Endothelin Receptor
  4. Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse  (Synonyms: Atrial natriuretic factor (1-28) (rat, mouse))

Cat. No.: HY-P1236 Purity: 99.46%
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Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.

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Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse Chemical Structure

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse Chemical Structure

CAS No. : 88898-17-3

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500 μg USD 180 In-stock
1 mg USD 280 In-stock
5 mg USD 980 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse:

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse Related Antibodies

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Description

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.

IC50 & Target

Endothelin-1[1]
In Vitro

Rat ANP (1-28) and rat BNP-45, which are the respective major circulating forms of ANP and BNP in rats, potently inhibited Ang II-stimulated endothelin-1 secretion in a concentration-dependent manner. Rat ANP (5-25) is less effective that Rat ANP(1-28) with respect to inhibiting immunoreactive (ir)-endothelin-1 secretion and increasing cellular cyclic GMP. Rat ANP (1-28) inhibits the secretion of ir-endothelin-1 in a concentration-dependent manner between 0.01 and 1 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse Related Antibodies
Molecular Weight

3062.41

Formula

C128H205N45O39S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys7-Cys23)
Sequence Shortening

SLRRSSCFGGRIDRIGAQSGLGCNSFRY (Disulfide bridge: Cys7-Cys23)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (32.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3265 mL 1.6327 mL 3.2654 mL
5 mM 0.0653 mL 0.3265 mL 0.6531 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3265 mL 1.6327 mL 3.2654 mL 8.1635 mL
5 mM 0.0653 mL 0.3265 mL 0.6531 mL 1.6327 mL
10 mM 0.0327 mL 0.1633 mL 0.3265 mL 0.8164 mL
15 mM 0.0218 mL 0.1088 mL 0.2177 mL 0.5442 mL
20 mM 0.0163 mL 0.0816 mL 0.1633 mL 0.4082 mL
25 mM 0.0131 mL 0.0653 mL 0.1306 mL 0.3265 mL
30 mM 0.0109 mL 0.0544 mL 0.1088 mL 0.2721 mL
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Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse88898-17-3Atrial natriuretic factor (1-28) (rat, mouse)Endothelin ReceptorInhibitorinhibitorinhibit

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