2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial Antibiotic DNA/RNA Synthesis
  4. Azaserine

Azaserine  (Synonyms: CI-337; O-Diazoacetyl-L-serine; P-165)

Cat. No.: HY-B0919 Purity: 99.91%
COA Handling Instructions

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Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic, it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection.

For research use only. We do not sell to patients.

Azaserine Chemical Structure

Azaserine Chemical Structure

CAS No. : 115-02-6

Size Price Stock Quantity
5 mg USD 62 In-stock
10 mg USD 99 In-stock
25 mg USD 210 In-stock
50 mg USD 340 In-stock
100 mg USD 540 In-stock
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Based on 2 publication(s) in Google Scholar

Azaserine Related Antibodies

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Description

Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic, it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection[1][2][3][4][5].

In Vitro

Azaserine (100 μg/mL; 6 h) causes some specific types of morphological changes of the sensitive organisms such as the characteristic elongation of Candida albicans cells[2].
? Azaserine (0-10 μM) inhibits the growth of E. coli strains with MIC values of 12.11, 51.9, 69.2 and 69.2 μg/mL for UTH 4, UTH 7036, UTH 7048 and UTH 7049[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azaserine Related Antibodies
In Vivo

Azaserine (5 mg/kg; i.p. once or twice a week for 6 months) induces tumor in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 5 mg/kg once or twice a week for 6 month
Result: After 1 year most pancreases from treated rats were diffusely abnormal and contained many hyperplastic nodules and adenomas and more than rats one-quarter showed pancreatic adenocarcinoma.
Molecular Weight

173.13

Formula

C5H7N3O4
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

N[C@@H](COC(C=[N+]=[N-])=O)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (288.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7760 mL 28.8800 mL 57.7601 mL
5 mM 1.1552 mL 5.7760 mL 11.5520 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.96%

COA (244 KB) HNMR (178 KB) LCMS (90 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.7760 mL 28.8800 mL 57.7601 mL 144.4002 mL
5 mM 1.1552 mL 5.7760 mL 11.5520 mL 28.8800 mL
10 mM 0.5776 mL 2.8880 mL 5.7760 mL 14.4400 mL
15 mM 0.3851 mL 1.9253 mL 3.8507 mL 9.6267 mL
20 mM 0.2888 mL 1.4440 mL 2.8880 mL 7.2200 mL
25 mM 0.2310 mL 1.1552 mL 2.3104 mL 5.7760 mL
30 mM 0.1925 mL 0.9627 mL 1.9253 mL 4.8133 mL
40 mM 0.1444 mL 0.7220 mL 1.4440 mL 3.6100 mL
50 mM 0.1155 mL 0.5776 mL 1.1552 mL 2.8880 mL
60 mM 0.0963 mL 0.4813 mL 0.9627 mL 2.4067 mL
80 mM 0.0722 mL 0.3610 mL 0.7220 mL 1.8050 mL
100 mM 0.0578 mL 0.2888 mL 0.5776 mL 1.4440 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Azaserine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azaserine115-02-6CI-337 O-Diazoacetyl-L-serine P-165CI337CI 337P165P 165P-165BacterialAntibioticDNA/RNA Synthesiscompetitiveantibacterialantibioticanti-tumortumor inducerE. coliCandida albicansratInhibitorinhibitorinhibit

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