2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Bemegride

Bemegride  (Synonyms: 3-Ethyl-3-methylglutarimide; Bemegrid)

Cat. No.: HY-B1326 Purity: 99.96%
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Bemegride (3-Ethyl-3-methylglutarimide) is a central nervous system stimulant and antidote for barbiturate poisoning.

For research use only. We do not sell to patients.

Bemegride Chemical Structure

Bemegride Chemical Structure

CAS No. : 64-65-3

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Bemegride Related Antibodies

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Description

Bemegride (3-Ethyl-3-methylglutarimide) is a central nervous system stimulant and antidote for barbiturate poisoning[1][2].

IC50 & Target

GABAA receptor[1]
In Vitro

Bemegride has an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents. [1] Long-term oral administration to the rat of barbitone, alone or together with the analeptics bemegride or pentylenetetrazol, show that the intensity of the withdrawal syndrome generally parallels the degree of associated CNS depression[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bemegride Related Antibodies
Molecular Weight

155.19

Formula

C8H13NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CC(C)(CC)C1)NC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (206.20 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4437 mL 32.2186 mL 64.4371 mL
5 mM 1.2887 mL 6.4437 mL 12.8874 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.4437 mL 32.2186 mL 64.4371 mL 161.0929 mL
5 mM 1.2887 mL 6.4437 mL 12.8874 mL 32.2186 mL
10 mM 0.6444 mL 3.2219 mL 6.4437 mL 16.1093 mL
15 mM 0.4296 mL 2.1479 mL 4.2958 mL 10.7395 mL
20 mM 0.3222 mL 1.6109 mL 3.2219 mL 8.0546 mL
25 mM 0.2577 mL 1.2887 mL 2.5775 mL 6.4437 mL
30 mM 0.2148 mL 1.0740 mL 2.1479 mL 5.3698 mL
40 mM 0.1611 mL 0.8055 mL 1.6109 mL 4.0273 mL
50 mM 0.1289 mL 0.6444 mL 1.2887 mL 3.2219 mL
60 mM 0.1074 mL 0.5370 mL 1.0740 mL 2.6849 mL
80 mM 0.0805 mL 0.4027 mL 0.8055 mL 2.0137 mL
100 mM 0.0644 mL 0.3222 mL 0.6444 mL 1.6109 mL
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Bemegride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bemegride64-65-33-Ethyl-3-methylglutarimide BemegridGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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