Betamethasone hydrochloride

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Betamethasone hydrochloride is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone hydrochloride accelerates fetal lung maturation and induces gene expression and apoptosis.

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Betamethasone hydrochloride Chemical Structure

CAS No. : 956901-32-9

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Other In-stock Forms of Betamethasone hydrochloride:

Betamethasone

Other Forms of Betamethasone hydrochloride:

Betamethasone In-stock
Betamethasone acetate Get quote
Betamethasone disodium phosphate Get quote
Betamethasone valerate Get quote
Betamethasone (Standard) Get quote

1 Publications Citing Use of MCE Betamethasone hydrochloride

•Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2117004119. [Abstract]

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Description

In Vitro

Betamethasone (0.1-1 μM; 12 h) induces gene expression in L929 cells^[4].
Betamethasone (0.1-1 μM; 48 h) induces CEM C7 T-cells apoptosis^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation^[1]. Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rambouillet-Colombia ewes bred on a single occasion are received hypercapnic challenges^[1]
Dosage:	0.48 mg
Administration:	Injected into the fetal jugular vein at a rate of 1 ml/h (10 μg betamethasone/h) and maintained over the next 48 h.
Result:	Decreased cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 h of infusion. The reduction in CBF was diminished to about 25-30 % after 48 h of infusion.

Clinical Trial

Molecular Weight

428.92

Formula

C₂₂H₃₀ClFO₅

CAS No.

956901-32-9

SMILES

C[C@@]12[C@](C[C@H](C)[C@]2(O)C(CO)=O)([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C1)=O.Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Schwab M, et, al. Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol. 2000 Nov 1;528(Pt 3):619-32. [Content Brief]

[2]. Xie W, et, al. Betamethasone affects cerebral expressions of NF-kappaB and cytokines that correlate with pain behavior in a rat model of neuropathy. Ann Clin Lab Sci. Winter 2006;36(1):39-46. [Content Brief]

[3]. Kubin ME, et, al. Clinical Efficiency of Topical Calcipotriol/Betamethasone Treatment in Psoriasis Relies on Suppression of the Inflammatory TNFα - IL-23 - IL-17 Axis. Acta Derm Venereol. 2017 Apr 6;97(4):449-455. [Content Brief]

[4]. Hofmann TH, et, al. Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription. FEBS Lett. 1998 Dec 28;441(3):441-6. [Content Brief]