Betamethasone disodium phosphate (Synonyms: Betamethasone 21-phosphate disodium salt; Vista-Methasone)

Name: Betamethasone disodium phosphate
Brand: MedChemExpress
SKU: HY-13570C
Rating: 4.5 (1 reviews)

Cat. No.: HY-13570C Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) is a kind of corticosteroid, which is commonly used in the intralesional research of keloids.

For research use only. We do not sell to patients.

Betamethasone disodium phosphate Chemical Structure

CAS No. : 151-73-5

Size	Price	Stock	Quantity
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Betamethasone disodium phosphate:

Betamethasone In-stock
Betamethasone hydrochloride Get quote
Betamethasone acetate Get quote
Betamethasone 21-phosphate-d₅ Get quote
Betamethasone disodium phosphate (Standard) Get quote

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Description

Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) is a kind of corticosteroid, which is commonly used in the intralesional research of keloids^[1].

Clinical Trial

Molecular Weight

516.40

Formula

C₂₂H₂₈FNa₂O₈P

CAS No.

151-73-5

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](C[C@@H]([C@]2(O)C(COP(O[Na])(O[Na])=O)=O)C)([H])[C@@]3([H])[C@@]([C@@]4(C(CC3)=CC(C=C4)=O)C)([C@H](C1)O)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (193.65 mM; Need ultrasonic)

DMSO : 25 mg/mL (48.41 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9365 mL	9.6824 mL	19.3648 mL
5 mM	0.3873 mL	1.9365 mL	3.8730 mL
10 mM	0.1936 mL	0.9682 mL	1.9365 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (274 KB) SDS (557 KB)

COA (253 KB)

Handling Instructions (2659 KB)

References

[1]. Wang L, et al. Determination of betamethasone disodium phosphate in the in vitro media of PLGA microspheres by high-performance liquid chromatography. J Pharm Biomed Anal. 2002;28(3-4):629-635. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.9365 mL	9.6824 mL	19.3648 mL	48.4121 mL
	5 mM	0.3873 mL	1.9365 mL	3.8730 mL	9.6824 mL
	10 mM	0.1936 mL	0.9682 mL	1.9365 mL	4.8412 mL
	15 mM	0.1291 mL	0.6455 mL	1.2910 mL	3.2275 mL
	20 mM	0.0968 mL	0.4841 mL	0.9682 mL	2.4206 mL
	25 mM	0.0775 mL	0.3873 mL	0.7746 mL	1.9365 mL
	30 mM	0.0645 mL	0.3227 mL	0.6455 mL	1.6137 mL
	40 mM	0.0484 mL	0.2421 mL	0.4841 mL	1.2103 mL
H₂O	50 mM	0.0387 mL	0.1936 mL	0.3873 mL	0.9682 mL
	60 mM	0.0323 mL	0.1614 mL	0.3227 mL	0.8069 mL
	80 mM	0.0242 mL	0.1210 mL	0.2421 mL	0.6052 mL
	100 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.4841 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Betamethasone disodium phosphate Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Betamethasone disodium151-73-5Betamethasone 21-phosphate disodium Vista-MethasoneOthersInhibitorinhibitorinhibit

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Betamethasone disodium phosphate (Synonyms: Betamethasone 21-phosphate disodium salt; Vista-Methasone)

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Complete Stock Solution Preparation Table

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