2. GPCR/G Protein Apoptosis
  3. Angiotensin Receptor Apoptosis
  4. Candesartan Cilexetil

Candesartan Cilexetil  (Synonyms: TCV-116)

Cat. No.: HY-17505 Purity: 99.86%
COA Handling Instructions

Molarity Calculator

Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure.

For research use only. We do not sell to patients.

Candesartan Cilexetil Chemical Structure

Candesartan Cilexetil Chemical Structure

CAS No. : 145040-37-5

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 79 In-stock
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Solid
500 mg USD 72 In-stock
1 g USD 92 In-stock
5 g   Get quote  
10 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Candesartan Cilexetil:

Candesartan Cilexetil Related Antibodies

Top Publications Citing Use of Products

View All Angiotensin Receptor Isoform Specific Products:

View All Isoforms
AT1 Receptor AT2 Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure[1][2][3][4][5][6].

In Vitro

Candesartan Cilexetil (0.1-10 μM, 24 h) exhibits antiviral effects against ZIKV in HUVEC cells, HEK293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Candesartan Cilexetil Related Antibodies

Cell Viability Assay[1]

Cell Line: HUVEC cells, HEK293T cells
Concentration: 0.1 μM, 1 μM, 5 μM, 10 μM
Incubation Time: 24 h
Result: Showed a dose-dependent antiviral effect in ZIKV-infected HUVEC and HEK293T cells.
In Vivo

Candesartan Cilexetil (5 mg/kg, Oral gavage, once a day for 7 weeks) ameliorates myocardial remodeling and heart failure in Dahl salt-sensitive (DS) rats fed a high-salt diet[2].
Candesartan Cilexetil (1-10 mg/kg, Oral, once a day for 15 days) has an effect of skin wound healing in rats[3].
Candesartan Cilexetil (1-10 mg/kg, Administered through a stomach tube, once a day for 4-12 weeks) inhibits the increase in blood pressure in spontaneously hypertensive rats[5].
Candesartan Cilexetil (10 mg/kg, Oral, supplemented in drinking water, for 2-23 days) inhibits the synthesis of TGF-b1 and ameliorates the pulmonary fibrosis in bleomycin (HY-108345) induced pulmonary fibrosis model rats[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Dahl salt-sensitive hypertensive rats[2]
Dosage: 5 mg/kg
Administration: Oral gavage (p.o.)
Result: Increased body weight and decreased left ventricular end-diastolic diameter.
Decreased the level of iNOS mRNA and ADM mRNA in the left ventricle (LV).
Increased the eNOS protein mass in the LV and decreased the immunoreactive ADM contents of LV.
Enhanced immunoreactivity for eNOS.
Significantly decreased the degree of perivascular fibrosis.
Animal Model: Skin wound model rat [3]
Dosage: 1 mg/kg, 10 mg/kg
Administration: Oral
Result: Showed 100% re-epithelization of the wound at 1 mg/kg.
Significantly suppressed angiogenesis at 10 mg/kg.
Clinical Trial
Molecular Weight

610.66

Formula

C33H34N6O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C2C(N=C(OCC)N2CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)=CC=C1)OC(OC(OC6CCCCC6)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (81.88 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6376 mL 8.1879 mL 16.3757 mL
5 mM 0.3275 mL 1.6376 mL 3.2751 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6376 mL 8.1879 mL 16.3757 mL 40.9393 mL
5 mM 0.3275 mL 1.6376 mL 3.2751 mL 8.1879 mL
10 mM 0.1638 mL 0.8188 mL 1.6376 mL 4.0939 mL
15 mM 0.1092 mL 0.5459 mL 1.0917 mL 2.7293 mL
20 mM 0.0819 mL 0.4094 mL 0.8188 mL 2.0470 mL
25 mM 0.0655 mL 0.3275 mL 0.6550 mL 1.6376 mL
30 mM 0.0546 mL 0.2729 mL 0.5459 mL 1.3646 mL
40 mM 0.0409 mL 0.2047 mL 0.4094 mL 1.0235 mL
50 mM 0.0328 mL 0.1638 mL 0.3275 mL 0.8188 mL
60 mM 0.0273 mL 0.1365 mL 0.2729 mL 0.6823 mL
80 mM 0.0205 mL 0.1023 mL 0.2047 mL 0.5117 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Candesartan Cilexetil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Candesartan Cilexetil145040-37-5TCV-116TCV116TCV 116Angiotensin ReceptorApoptosisHUVEC cellsHEK293T cellsDahl salt-sensitiveSkin woundhigh blood pressureInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Candesartan Cilexetil
Cat. No.:
HY-17505
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.