2. GPCR/G Protein Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Angiotensin Receptor PPAR
  4. Candesartan

Candesartan  (Synonyms: CV 11974)

Cat. No.: HY-B0205 Purity: 98.03%
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Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI).

For research use only. We do not sell to patients.

Candesartan Chemical Structure

Candesartan Chemical Structure

CAS No. : 139481-59-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 80 In-stock
Solution
10 mM * 1 mL in DMSO USD 80 In-stock
Solid
5 mg USD 47 In-stock
10 mg USD 73 In-stock
50 mg USD 264 In-stock
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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Candesartan:

Candesartan Related Antibodies

Top Publications Citing Use of Products

    Candesartan purchased from MedChemExpress. Usage Cited in: Biomedicines. 2022, 10(12), 3131.

    Candesartan (5 μM; pretreat for 6 h) inhibits Ang II-induced CtBP1 transcription in 3T3-L1 cells.

    Candesartan purchased from MedChemExpress. Usage Cited in: Biomedicines. 2022, 10(12), 3131.

    Candesartan (5 μM; pretreat for 6 h) inhibits Ang II-induced CtBP1 expression in 3T3-L1 cells.

    View All Angiotensin Receptor Isoform Specific Products:

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    AT1 Receptor AT2 Receptor

    View All PPAR Isoform Specific Products:

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    PPARα PPARβ/δ PPARγ PPAR PPARδ

    • Biological Activity

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    Description

    Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI)[1][2][3].

    IC50 & Target

    PPAR-γ

     

    Cellular Effect
    Cell Line Type Value Description References
    CHO-K1 IC50
    0.69 nM
    Compound: Candesartan
    Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation counting
    Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation counting
    		[PMID: 26824643]
    In Vivo

    Candesartan (i.p.; 1 mg/kg/day; continuously for 1, 3 or 28 dpi) has neuroprotective effect, reducing neuronal injury, decreasing lesion volume and microglial activation, protecting CBF and improving functional behavior in a mouse model of TBI[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL/6 mice (nine-week-old, male, 22–28 g)[3]
    Dosage: 1 mg/kg
    Administration: i.p.; 1 mg/kg/day; continuously for 1, 3 or 28 dpi.
    Result: Reduced the lesion volume after CCI injury by approximately 50%, decreased the number of dying neurons, lessened the number of activated microglial cells, protected cerebral blood flow (CBF), and reduced the expression of the cytokine TGFß1 while increasing expression of TGFB3.
    Showed good motor skills on the rotarod 3 days after injury, and improved performance in the Morris water maze 4 weeks after injury.
    Clinical Trial
    Molecular Weight

    440.45

    Formula

    C24H20N6O3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(C1=C2C(N=C(OCC)N2CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)=CC=C1)O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (227.04 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2704 mL 11.3520 mL 22.7041 mL
    5 mM 0.4541 mL 2.2704 mL 4.5408 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (5.68 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (5.68 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.2704 mL 11.3520 mL 22.7041 mL 56.7601 mL
    5 mM 0.4541 mL 2.2704 mL 4.5408 mL 11.3520 mL
    10 mM 0.2270 mL 1.1352 mL 2.2704 mL 5.6760 mL
    15 mM 0.1514 mL 0.7568 mL 1.5136 mL 3.7840 mL
    20 mM 0.1135 mL 0.5676 mL 1.1352 mL 2.8380 mL
    25 mM 0.0908 mL 0.4541 mL 0.9082 mL 2.2704 mL
    30 mM 0.0757 mL 0.3784 mL 0.7568 mL 1.8920 mL
    40 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.4190 mL
    50 mM 0.0454 mL 0.2270 mL 0.4541 mL 1.1352 mL
    60 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.9460 mL
    80 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.7095 mL
    100 mM 0.0227 mL 0.1135 mL 0.2270 mL 0.5676 mL
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    Candesartan Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Candesartan139481-59-7CV 11974CV11974CV-11974Angiotensin ReceptorPPARPeroxisome proliferator-activated receptorsoralangiotensin II AT1-ReceptorPPAR-γantihypertensivehypertensionhronic heart failure (CHF)Traumatic brain injury (TBI)Inhibitorinhibitorinhibit

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