2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species Endogenous Metabolite
  4. Canthaxanthin

Canthaxanthin  (Synonyms: E 161g; all-trans-Canthaxanthin)

Cat. No.: HY-B1960 Purity: ≥98.0%
SDS COA Handling Instructions

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Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties.

For research use only. We do not sell to patients.

Canthaxanthin Chemical Structure

Canthaxanthin Chemical Structure

CAS No. : 514-78-3

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Based on 2 publication(s) in Google Scholar

Other Forms of Canthaxanthin:

Canthaxanthin Related Antibodies

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Description

Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Canthaxanthin enrichment of LDL has the potential to protect cholesterol from oxidation. In addition to its free radical scavenging and antioxidant properties (e.g., the induction of catalase and superoxide dismutase), canthaxanthin shows immunomodulatory activity (e.g. enhancing the proliferation and function of immune competent cells) and plays important role in gap junction communication (e.g. induction of the transmembrane protein connexin)[1]. At concentrations of 0.1 to 1 x 1000 μM, canthaxanthin significantly reduces the overall number of tumor cells. The greatest inhibition is observed at a canthaxanthin concentration of 1000 after 72 h and 96 h of incubation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Canthaxanthin Related Antibodies
In Vivo

Canthaxanthin alters the protective ability of tissues against oxidative stress. Canthaxanthin treatment for 15 d at the dose of 14 μg/kg body weight results in hepatic incorporation of the carotenoid, which is maximum in liver and reaches 0.52 ± 0.05 nmol/g liver. Glutathione peroxidase activity is 35% lower and catalase (59%) and manganese superoxide dismutase (28%) activities are higher in canthaxanthin-treated mice than in controls[3]. Canthaxanthin inhibit the growth of mammary tumors in mice and the anti-tumor activity is also influenced by the supplemental dose[4]. Diet supplementation with canthaxanthin for 3 weeks prior to the carcinogen results in a 65% reduction in the number of mammary cancers by a mechanism not involving pro-vitamin A activity[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

564.84

Formula

C40H52O2
CAS No.
Appearance

Solid

Color

Reddish brown to black

SMILES

CC(/C=C/C(C(C)(CCC1=O)C)=C1C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C(C(C)(CCC2=O)C)=C2C
Structure Classification
Initial Source

extremely halophilic bacteria
Shipping

Shipping with dry ice.
Storage

-20°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

Chloroform : 25 mg/mL (44.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7704 mL 8.8521 mL 17.7041 mL
5 mM 0.3541 mL 1.7704 mL 3.5408 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (240 KB) HNMR (228 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[3]

Mice: Female 6-wk-old Balb/c mice are randomly divided into two groups (n = 10/group). The control group receives olive oil alone (vehicle) and the canthaxanthin-treated group receives canthaxanthin at a dose of 14 μg/kg body weight per day. At the end of the treatment, mice are killed by cervical dislocation and liver is excised, frozen in liquid nitrogen and stored at −80°C[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Chloroform 1 mM 1.7704 mL 8.8521 mL 17.7041 mL 44.2603 mL
5 mM 0.3541 mL 1.7704 mL 3.5408 mL 8.8521 mL
10 mM 0.1770 mL 0.8852 mL 1.7704 mL 4.4260 mL
15 mM 0.1180 mL 0.5901 mL 1.1803 mL 2.9507 mL
20 mM 0.0885 mL 0.4426 mL 0.8852 mL 2.2130 mL
25 mM 0.0708 mL 0.3541 mL 0.7082 mL 1.7704 mL
30 mM 0.0590 mL 0.2951 mL 0.5901 mL 1.4753 mL
40 mM 0.0443 mL 0.2213 mL 0.4426 mL 1.1065 mL
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Canthaxanthin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Canthaxanthin514-78-3E 161g all-trans-CanthaxanthinReactive Oxygen SpeciesEndogenous MetaboliteInhibitorinhibitorinhibit

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