2. Anti-infection
  3. SARS-CoV
  4. Casirivimab

Casirivimab  (Synonyms: REGN10933)

Cat. No.: HY-P99341 Purity: ≥95.0%
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Casirivimab (REGN10933) is a human monoclonal antibody that targets the SARS-CoV-2 virus, which causes COVID-19. Casirivimab is ineffective against COVID-19 variants. Casirivimab can be used in combination with Imdevimab (HY-P99342), which alters the lung response of K18-hACE2 mice to the SARS-CoV-2 δ variant, effectively reducing viral load and improving symptoms.

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CAS No. : 2415933-42-3

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Description

Casirivimab (REGN10933) is a human monoclonal antibody that targets the SARS-CoV-2 virus, which causes COVID-19. Casirivimab is ineffective against COVID-19 variants. Casirivimab can be used in combination with Imdevimab (HY-P99342), which alters the lung response of K18-hACE2 mice to the SARS-CoV-2 δ variant, effectively reducing viral load and improving symptoms[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Human
IC50 & Target

SARS-CoV-2[1]
In Vivo

Casirivimab (400 μg (Casirivimab and imdevimab), intraperitoneal injection, single dose) has shown positive results against the δ variant when used in combination with imdevimab, but its antiviral effectiveness appears to be weakened when dealing with the Omicron variant[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: K18-hACE2 mice vaccinated with the SARS-CoV-2 δ or Omicron variant[2]
Dosage: 400μg; single dose
Administration: Intraperitoneal injection (i.p.)
Result: Decreased amount of subgenomic E RNA (sgE RNA), which reduced the viral load and improved lung pathology in δ. Weakened antiviral effectiveness in the body against Omicron.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Casirivimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
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Casirivimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Casirivimab2415933-42-3REGN10933REGN 10933REGN-10933SARS-CoVSARS coronavirusAntiviralviral loadInhibitorinhibitorinhibit

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