Cefprozil monohydrate 

Cefprozil monohydrate is a second-generation cephalosporin type antibiotic. Cefprozil monohydrate exhibits broad-spectrum antibacterial activity, and is orally active^[1][2].

Cefprozil monohydrate inhibits S. pyogenes, S. pneumoniae, S. agalactiae, S. aureus (methicillin-susceptible), H. influenzae, M. catarrhalis, E. coli with MIC₉₀s of 0.04, 0.23, 0.3, 1.4, 6.7, 4.5, 12.2 mg/L, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefprozil monohydrate (two doses, injection) exhibits antibacterial activity against E. coli, H. influenzae, K. pneumoniae, P. mirabilis, S. aureus (β-lactamase-negative), S. aureus (β-lactamase-positive), S. pneumoniae, and S. pyogenes in mouse models, with ED₅₀s of 2.0, 3.1, 2.8, 1.5, 0.04, 18, 1.0 and 0.08 mg/kg, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

407.44

C₁₈H₂₁N₃O₆S

121123-17-9

Solid

White to off-white

OC(C(N1[C@@]2([H])[C@H](NC([C@@H](C3=CC=C(O)C=C3)N)=O)C1=O)=C(CS2)/C=C/C)=O.O

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 2 years; -20°C, 1 year (protect from light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

• [1]. J C Fung-Tom, et al. Antibacterial activities of cefprozil compared with those of 13 oral cephems and 3 macrolides. Antimicrob Agents Chemother. 1995 Feb;39(2):533-8.  [Content Brief]

  [2]. Wiseman LR, et al., Cefprozil. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic potential. Drugs. 1993 Feb;45(2):295-317.