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  4. Chitinase-IN-2

Chitinase-IN-2 is a insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide; 50 μM/20 μM compound concentration's inhibitory percentage are 98%/92% for chitinase/N- acetyl-hexosaminidase respectively.

For research use only. We do not sell to patients.

Chitinase-IN-2 Chemical Structure

Chitinase-IN-2 Chemical Structure

CAS No. : 1579991-63-1

Size Price Stock Quantity
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 374 In-stock
Solution
10 mM * 1 mL in DMSO USD 374 In-stock
Oil
5 mg USD 340 In-stock
10 mg USD 540 In-stock
50 mg USD 1300 In-stock
100 mg USD 1900 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Chitinase-IN-2:

Chitinase-IN-2 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Chitinase-IN-2

WB

    Chitinase-IN-2 purchased from MedChemExpress. Usage Cited in: Neuroscience. 2017 May 10;355:61-70.  [Abstract]

    Measurement of Aβ oligomers by immunohistochemical staining (×200) and western blot in experimental animals. Whether in the hippocampus (A) or cortex (B), there are much more Aβ oligomers in theAD rats compared to controls (p<0.05). Compared with the AD group, expression of Aβ oligomers in the cortex and hippocampus following chitinase treatment in AD rats is reduced (p<0.05), while the chitinase inhibitor (chitinase-IN-2) increases the Aβ oligomer expression (p<0.05)

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Chitinase-IN-2 is a insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide; 50 μM/20 μM compound concentration's inhibitory percentage are 98%/92% for chitinase/N- acetyl-hexosaminidase respectively.

    Molecular Weight

    395.48

    Formula

    C20H21N5O2S
    CAS No.
    Appearance

    Oil

    Color

    Yellow to orange

    SMILES

    O=C(C1=CC=CC2=C1C3=CC=C2N(C)C)N(CCNCC4=NN=C(C)S4)C3=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Pure form -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 53 mg/mL (134.01 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : ≥ 50 mg/mL (126.43 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5286 mL 12.6429 mL 25.2857 mL
    5 mM 0.5057 mL 2.5286 mL 5.0571 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.38%

    COA (252 KB) HNMR (132 KB) LCMS (94 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.5286 mL 12.6429 mL 25.2857 mL 63.2143 mL
    5 mM 0.5057 mL 2.5286 mL 5.0571 mL 12.6429 mL
    10 mM 0.2529 mL 1.2643 mL 2.5286 mL 6.3214 mL
    15 mM 0.1686 mL 0.8429 mL 1.6857 mL 4.2143 mL
    20 mM 0.1264 mL 0.6321 mL 1.2643 mL 3.1607 mL
    25 mM 0.1011 mL 0.5057 mL 1.0114 mL 2.5286 mL
    30 mM 0.0843 mL 0.4214 mL 0.8429 mL 2.1071 mL
    40 mM 0.0632 mL 0.3161 mL 0.6321 mL 1.5804 mL
    50 mM 0.0506 mL 0.2529 mL 0.5057 mL 1.2643 mL
    60 mM 0.0421 mL 0.2107 mL 0.4214 mL 1.0536 mL
    80 mM 0.0316 mL 0.1580 mL 0.3161 mL 0.7902 mL
    100 mM 0.0253 mL 0.1264 mL 0.2529 mL 0.6321 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Chitinase-IN-2 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Chitinase-IN-21579991-63-1OthersInhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
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