2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. DC1SMe

DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

For research use only. We do not sell to patients.

DC1SMe Chemical Structure

DC1SMe Chemical Structure

CAS No. : 501666-85-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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5 mg In-stock
10 mg In-stock
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Based on 1 publication(s) in Google Scholar

DC1SMe Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

IC50 & Target

Duocarmycins

 

Cellular Effect
Cell Line Type Value Description References
COLO 205 IC50
250 pM
Compound: 23, DC1SMe
Cytotoxicity against human COLO205 cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human COLO205 cells assessed as cell survival after 72 hrs by clonogenic assay
[PMID: 22148292]
HL-60 IC50
32 pM
Compound: 23, DC1SMe
Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay
[PMID: 22148292]
NAMALVA IC50
10 pM
Compound: 23, DC1SMe
Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay
[PMID: 22148292]
Ramos IC50
22 pM
Compound: 23, DC1SMe
Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs by clonogenic assay
[PMID: 22148292]
Molecular Weight

684.23

Formula

C35H30ClN5O4S2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(N1)=CC2=C1C=CC(NC(CCSSC)=O)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Purity & Documentation

Purity: ≥98.0%

SDS (252 KB)

COA (248 KB) HNMR (374 KB)

Handling Instructions (2659 KB)
References
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DC1SMe Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DC1SMe501666-85-9ADC CytotoxinADC PayloadInhibitorinhibitorinhibit

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HY-112898
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