DL-threo-2-methylisocitrate sodium

Name: DL-threo-2-methylisocitrate sodium
Brand: MedChemExpress
SKU: HY-16581A
Rating: 4.5 (1 reviews)

Cat. No.: HY-16581A Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1(ICL1).

For research use only. We do not sell to patients.

DL-threo-2-methylisocitrate sodium Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 660	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1176	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1800	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of DL-threo-2-methylisocitrate sodium:

DL-threo-2-methylisocitrate Get quote

1 Publications Citing Use of MCE DL-threo-2-methylisocitrate sodium

•Mol Plant Microbe Interact. 2019 Sep;32(9):1148-1161. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1(ICL1). IC50 value: Target: The Km of purified recombinant ICL1 for threo-D(s)L(s)-isocitrate (ICA) was determined to be 188 μM using Michaelis-Menten non-linear least squares fit, with a kcat of 5.24 s-1. The Km for DL-threo-2-methylisocitrate (MICA) was approximately fourfold higher at 718 μM with a kcat of 1.25 s-1.

Molecular Weight

544.19

Formula

C₁₄H₁₄Na₆O₁₄

Appearance

Solid

Color

White to off-white

SMILES

O[C@@](C)(C([O-])=O)[C@@]([H])(C([O-])=O)CC([O-])=O.O[C@](C)(C([O-])=O)[C@]([H])(C([O-])=O)CC([O-])=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (183.76 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8376 mL	9.1880 mL	18.3759 mL
5 mM	0.3675 mL	1.8376 mL	3.6752 mL
10 mM	0.1838 mL	0.9188 mL	1.8376 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (280 KB) SDS (251 KB)

COA (261 KB) HNMR (273 KB)

Handling Instructions (2659 KB)

References

[1]. Gould TA, et al. Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis. Mol Microbiol. 2006 Aug;61(4):940-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.8376 mL	9.1880 mL	18.3759 mL	45.9398 mL
	5 mM	0.3675 mL	1.8376 mL	3.6752 mL	9.1880 mL
	10 mM	0.1838 mL	0.9188 mL	1.8376 mL	4.5940 mL
	15 mM	0.1225 mL	0.6125 mL	1.2251 mL	3.0627 mL
	20 mM	0.0919 mL	0.4594 mL	0.9188 mL	2.2970 mL
	25 mM	0.0735 mL	0.3675 mL	0.7350 mL	1.8376 mL
	30 mM	0.0613 mL	0.3063 mL	0.6125 mL	1.5313 mL
	40 mM	0.0459 mL	0.2297 mL	0.4594 mL	1.1485 mL
	50 mM	0.0368 mL	0.1838 mL	0.3675 mL	0.9188 mL
	60 mM	0.0306 mL	0.1531 mL	0.3063 mL	0.7657 mL
	80 mM	0.0230 mL	0.1148 mL	0.2297 mL	0.5742 mL
	100 mM	0.0184 mL	0.0919 mL	0.1838 mL	0.4594 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.