MC-DOXHZN (Synonyms: (E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone)

Cat. No.: HY-16261A: FAQs
Data Sheet Handling Instructions

Molarity Calculator

MC-DOXHZN ((E/Z)-Aldoxorubicin) is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), with acid-sensitive properties.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (MC-DOXHZN hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

MC-DOXHZN Chemical Structure

CAS No. : 151038-96-9

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Other Forms of MC-DOXHZN:

Aldoxorubicin In-stock
MC-DOXHZN hydrochloride Get quote

5 Publications Citing Use of MCE MC-DOXHZN

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Biological Activity
Purity & Documentation
References
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Description

MC-DOXHZN ((E/Z)-Aldoxorubicin) is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), with acid-sensitive properties^[1].

IC₅₀ & Target^[1]

Topoisomerase II

Daunorubicins/Doxorubicins

Molecular Weight

750.75

Formula

C₃₇H₄₂N₄O₁₃

CAS No.

151038-96-9

SMILES

[H][C@@]1(O[C@H]2C[C@@](/C(CO)=N\NC(CCCCCN3C(C=CC3=O)=O)=O)(O)CC(C2=C4O)=C(O)C5=C4C(C6=C(OC)C=CC=C6C5=O)=O)O[C@@H](C)[C@@H](O)[C@@H](N)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sevim Rollas, et al. Hydrazone, Amide, Carbamate, Macromolecular and Other Prodrugs of Doxorubicin. The Open Drug Delivery Journal, 2008, 2, 77-85.

MC-DOXHZN Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-DOXHZN151038-96-9(E/Z)-Aldoxorubicin Doxorubicin(6-maleimidocaproyl)hydrazoneTopoisomeraseDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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