Topoisomerase Inhibitors

Topoisomerase

Topo I

Topo II

Topoisomerase Inhibitors & Agonists

Product Name	Topoisomerase	Topo I	Topo II	Purity
Doxorubicin hydrochloride		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM	99.90%
Etoposide			Topoisomerase II	99.94%
Dxd		Topoisomerase I, IC₅₀: 0.31 μM		99.30%
SN-38		Topoisomerase I		99.89%
Camptothecin		Topoisomerase I, IC₅₀: 679 nM		99.86%
Irinotecan		Topoisomerase I		99.97%
Topotecan hydrochloride		Topoisomerase I		99.89%
Daunorubicin hydrochloride			Topoisomerase II	99.67%
Mitoxantrone			Topoisomerase II	98.70%
Epirubicin hydrochloride	Topoisomerase			99.16%
Irinotecan hydrochloride		Topoisomerase I		99.89%
Levofloxacin	TOPO IV			99.86%
Datopotamab deruxtecan		Topoisomerase I
Idarubicin hydrochloride			Topoisomerase II	99.94%
Betulinic acid		Topoisomerase I, IC₅₀: 5 μM		98.43%
Mitoxantrone dihydrochloride			Topoisomerase II	99.55%
β-Lapachone		Topoisomerase I		99.99%
Pirarubicin			Topoisomerase II	99.61%
Irinotecan hydrochloride trihydrate		Topoisomerase I		99.89%
Teniposide			Topoisomerase II	98.64%
Belotecan hydrochloride		Top1		99.88%
Dxd-d₅		Topoisomerase I, IC₅₀: 0.31 μM		98.84%
PNU-159682		Topoisomerase I		98.57%
Aldoxorubicin			Topoisomerase II
Aurintricarboxylic acid			Topoisomerase II
Banoxantrone dihydrochloride			Topoisomerase II	99.46%
Etoposide phosphate			Topoisomerase II
Aclacinomycin A		Topoisomerase I	Topoisomerase II	99.30%
Nalidixic acid	Topoisomerase			99.97%
Proscillaridin A		Topoisomerase I, IC₅₀: 30 nM	Topoisomerase II, IC₅₀: 100 nM	99.74%
Levofloxacin hydrate	TOPO IV			99.93%
(S)-10-Hydroxycamptothecin		Topoisomerase I		99.38%
Pirarubicin Hydrochloride			Topoisomerase II	98.56%
Pixantrone			Topoisomerase II	98.38%
Bisantrene			Topoisomerase II	98.08%
Amsacrine			Topoisomerase II	99.95%
Gatifloxacin			Topoisomerase II, IC₅₀: 36.7 μM	99.55%
PluriSIn #2			topoisomerase II alpha	≥98.0%
Ellipticine			Topoisomerase II	99.56%
Voreloxin Hydrochloride			Topoisomerase II	99.58%
MC-GGFG-AM-(10Me-11F-Camptothecin)		Topoisomerase I		98.06%
Amonafide			Topoisomerase II	99.92%
Amsacrine hydrochloride			Topoisomerase II	99.98%
Hycanthone		Topoisomerase I	Topoisomerase II	99.97%
TAS-103 dihydrochloride		Topoisomerase I	Topoisomerase II	98.87%
Indotecan		Topoisomerase I		≥98.0%
Coralyne chloride		Topoisomerase I		98.30%
Genz-644282		Topoisomerase I		99.53%
MC-DOXHZN hydrochloride			Topoisomerase II	98.04%
Chloroquinoxaline sulfonamide			topoisomerase II alpha topoisomerase II beta	99.06%
Ellipticine hydrochloride			Topoisomerase II	99.34%
9-Aminocamptothecin		Topoisomerase I		98.89%
Gatifloxacin hydrochloride			Topoisomerase II, : 36.7 μM	99.94%
Intoplicine		Topoisomerase I	Topoisomerase II	98.36%
Amrubicin			Topoisomerase II	≥98.0%
(±)-10-Hydroxycamptothecin		Topoisomerase I		99.57%
Daun02	Topoisomerase			98.72%
Gimatecan		Topoisomerase I		99.28%
(±)-Evodiamine		Top1		99.74%
Lurtotecan		Topoisomerase I		98.01%
LMP744 hydrochloride		Top1		99.70%
Groenlandicine		Topoisomerase I		99.87%
Flumequine			Topoisomerase II, IC₅₀: 15 μM
Karenitecin		Topoisomerase I		98.27%
Isodiospyrin		Topoisomerase I		99.77%
Garenoxacin Mesylate hydrate	TOPO IV, IC₅₀: 1.5-2.5 μg/mL			99.78%
Levofloxacin hydrochloride	TOPO IV			≥98.0%
Nalidixic acid sodium salt	Topoisomerase			99.74%
Podocarpusflavone A		Topoisomerase I, IC₅₀: 119.425 μM		99.62%
Aclacinomycin A hydrochloride		Topoisomerase I	Topoisomerase II
Epirubicin	Topoisomerase			98.45%
ARN-21934			topoisomerase II alpha topoisomerase II beta	98.08%
Indimitecan		Top1		98.03%
Elomotecan hydrochloride		Topoisomerase I	Topoisomerase II
SW044248		Topoisomerase I		99.60%
LMP517		Topoisomerase I	Topoisomerase II	99.58%
9-Hydroxyellipticine hydrochloride			Topoisomerase II	≥99.0%
LMP744		Top1		98.85%
Namitecan		Topoisomerase I		99.25%
Topotecan		Topoisomerase I
Doxorubicin		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM
Daunorubicin			Topoisomerase II
Topoisomerase II inhibitor 20			Topoisomerase II, IC₅₀: 0.98 μM
Topoisomerase I inhibitor 8		Topoisomerase I
CH-0793076		Topoisomerase I, IC₅₀: 2.3 μM
Seconeolitsine		Topoisomerase I, IC₅₀: 17 μM
Edotecarin		Topoisomerase I, IC₅₀: 50 nM		98.39%
CH-0793076 TFA		Topoisomerase I, IC₅₀: 2.3 μM		98.71%
Zabofloxacin		Topoisomerase I	Topoisomerase II	98.02%
Zabofloxacin hydrochloride		Topoisomerase I	Topoisomerase II	99.54%
Pixantrone free base			Topoisomerase II
TAS-103		Topoisomerase I	Topoisomerase II
MC-DOXHZN			Topoisomerase II
Topotecan hydrochloride hydrate		Topoisomerase I
Etoposide phosphate disodium			Topoisomerase II
Idarubicin			Topoisomerase II
Gatifloxacin sesquihydrate			Topoisomerase II, IC₅₀: 36.7 μM
Rebeccamycin		Topoisomerase I
Mitoxantrone diacetate			Topoisomerase II
Daunorubicin citrate			Topoisomerase II
Antitumor agent-63		Top1
Silatecan		Topoisomerase I
Topoisomerase II inhibitor 9			Topoisomerase II, IC₅₀: 0.97 μM
Topo I/COX-2-IN-1		Topoisomerase I, IC₅₀: 4.42 μM
Bimolane			Topoisomerase II
T-2513 hydrochloride		Topoisomerase I
TOPOI/PARP-1-IN-2		Top1, IC₅₀: 46.2 nM
Topo I/COX-2-IN-2		Topoisomerase I, IC₅₀: 0.90 μM
Topoisomerase II inhibitor 11			Topoisomerase II, IC₅₀: 2.89 μM
CS1			topoisomerase II alpha
T-2513		Topoisomerase I
Razoxane			Topoisomerase II	99.16%
Topoisomerase IIα-IN-3			topoisomerase II alpha
Heliquinomycin		Topoisomerase I	Topoisomerase II
Topoisomerase II/EGFR-IN-1			Topoisomerase II
Anticancer agent 75			Topoisomerase II
CP-67804			Topoisomerase II
AQ4			Topoisomerase II
Pixantrone hydrochloride			Topoisomerase II
Topoisomerase II inhibitor 4			Topoisomerase II
Topoisomerase IIα-IN-6			topoisomerase II alpha, IC₅₀: 0.67 μM
Topoisomerase IIα-IN-2			topoisomerase II alpha topoisomerase II beta
Topoisomerase IIα-IN-4			topoisomerase II alpha, IC₅₀: 3.8 μM topoisomerase II beta, IC₅₀: 10.1 μM
ZLHQ-5f		Top1
3-Fluoro-evodiamine glucose		Topoisomerase I	Topoisomerase II
Topo I-IN-1		Topoisomerase I
Topoisomerase I/II inhibitor 6		Topoisomerase I, IC₅₀: 4.77 μM	Topoisomerase II, IC₅₀: 15 μM
EGFR-IN-116			Topoisomerase II, IC₅₀: 19.74 μM
Top/HDAC-IN-2		Top1	Topoisomerase II
Anti-MRSA agent 7	TOPO IV, IC₅₀: 0.059 μM (E. coli ) TOPO IV, IC₅₀: 0.341 μM (S. aureus)
Topoisomerase II inhibitor 18			Topoisomerase II, IC₅₀: 7.5 μM
Elomotecan		Topoisomerase I	Topoisomerase II
Topoisomerase II inhibitor 5			Topoisomerase II
LE01		Topoisomerase I
HSP90-IN-13	Topoisomerase-2, IC₅₀: 25.85 nM
Topoisomerase I inhibitor 2		Topoisomerase I, IC₅₀: 0.58 μM
Topoisomerase II inhibitor 20 TFA			Topoisomerase II, IC₅₀: 0.98 μM
iNOS/TopoI-IN-1		Topoisomerase I, Ki: 2.72 μM
Topoisomerase II inhibitor 10			Topoisomerase II, IC₅₀: 7.45 μM
Salvicine			Topoisomerase II, IC₅₀: 3 μM
Topoisomerase IV inhibitor 1	TOPO IV, IC₅₀: 0.23 μM
Topoisomerase II inhibitor 13			Topoisomerase II	99.26%
EGFR-IN-57			topoisomerase II beta, IC₅₀: 0.13 μM
Topoisomerase IIα-IN-1			topoisomerase II alpha topoisomerase II beta
Huanglongmycin N		Topoisomerase I, EC₅₀: 14 μM
Topoisomerase IIα-IN-8			topoisomerase II alpha
CP-67015			Topoisomerase II
Tapcin		Topoisomerase I, IC₅₀: 203 nM	Topoisomerase II, IC₅₀: 71 nM
Topoisomerase I inhibitor 12		Topoisomerase I
BNS-22			topoisomerase II alpha, IC₅₀: 2.8 μM (in human) topoisomerase II beta, IC₅₀: 0.42 μM (in human)
Topoisomerase II inhibitor 17			Topoisomerase II, IC₅₀: 0.23 μM
Topoisomerase I/II inhibitor 2		Topoisomerase I	Topoisomerase II
Saintopin		Topoisomerase I	Topoisomerase II
Intoplicine dimesylate		Topoisomerase I	Topoisomerase II	98.28%
Topoisomerase IV inhibitor 2	TOPO IV, IC₅₀: 0.35 μM
Topoisomerase II inhibitor 7			topoisomerase II alpha, IC₅₀: 3.19 μM
Topoisomerase IIα-IN-7			topoisomerase II alpha, IC₅₀: 7.7 μM
Niranthin	Topoisomerase
Epolactaene			Topoisomerase II, IC₅₀: 10 μM
Topoisomerase I inhibitor 3		Topoisomerase I
Topoisomerase II inhibitor 19			Topoisomerase II, IC₅₀: 0.34 μM
Corydamine		Topoisomerase I	Topoisomerase II
TP0480066			Topoisomerase II
AZD5099			Topoisomerase II
Topoisomerase I inhibitor 16		Topoisomerase I
TP3011		Topoisomerase I
Topoisomerase II inhibitor 8			Topoisomerase II, IC₅₀: 0.52 μM
Topoisomerase I/II inhibitor 3		Topoisomerase I	Topoisomerase II
Gatifloxacin mesylate			Topoisomerase II, IC₅₀: 36.7 μM
Voreloxin			Topoisomerase II	99.26%
Topoisomerase IIα-IN-5			topoisomerase II alpha
Thaspine acetate		Topoisomerase I	Topoisomerase II
Antibacterial agent 229	TOPO IV, IC₅₀: 10.88 μM
(-)-BO 2367			Topoisomerase II
Garenoxacin	TOPO IV, IC₅₀: 1.5-2.5 μg/mL
HU 331			Topoisomerase II
Luotonin F			Topoisomerase II
Topovale		Topoisomerase I
NK 314			topoisomerase II alpha

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