2. Neuronal Signaling
  3. Serotonin Transporter
  4. Dapoxetine hydrochloride

Dapoxetine hydrochloride  (Synonyms: LY-210448 hydrochloride)

Cat. No.: HY-B0304A Purity: 99.96%
COA Handling Instructions

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Dapoxetine (LY-210448) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE).

For research use only. We do not sell to patients.

Dapoxetine hydrochloride Chemical Structure

Dapoxetine hydrochloride Chemical Structure

CAS No. : 129938-20-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 88 In-stock
Solution
10 mM * 1 mL in DMSO USD 88 In-stock
Solid
5 mg USD 35 In-stock
10 mg USD 50 In-stock
50 mg USD 80 In-stock
100 mg USD 130 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Dapoxetine hydrochloride:

Dapoxetine hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Dapoxetine hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dapoxetine (LY-210448) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE)[1].

IC50 & Target

Target: serotonin reuptake[1]
In Vitro

Dapoxetine hydrochloride binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine?dopamine.
Dapoxetine hydrochloride inhibits the uptake of [3H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [3H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [3H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dapoxetine hydrochloride Related Antibodies
In Vivo

Dapoxetine hydrochloride (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats[2]
Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg
Administration: Oral gavage; 1-10 mg/kg; once daily
Result: Reverted most of the changes made by testosterone injection
Clinical Trial
Molecular Weight

341.87

Formula

C21H24ClNO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN(C)[C@H](C1=CC=CC=C1)CCOC2=C3C(C=CC=C3)=CC=C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (292.51 mM; Need ultrasonic)

DMSO : ≥ 32 mg/mL (93.60 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9251 mL 14.6254 mL 29.2509 mL
5 mM 0.5850 mL 2.9251 mL 5.8502 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.96%

COA (254 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.9251 mL 14.6254 mL 29.2509 mL 73.1272 mL
5 mM 0.5850 mL 2.9251 mL 5.8502 mL 14.6254 mL
10 mM 0.2925 mL 1.4625 mL 2.9251 mL 7.3127 mL
15 mM 0.1950 mL 0.9750 mL 1.9501 mL 4.8751 mL
20 mM 0.1463 mL 0.7313 mL 1.4625 mL 3.6564 mL
25 mM 0.1170 mL 0.5850 mL 1.1700 mL 2.9251 mL
30 mM 0.0975 mL 0.4875 mL 0.9750 mL 2.4376 mL
40 mM 0.0731 mL 0.3656 mL 0.7313 mL 1.8282 mL
50 mM 0.0585 mL 0.2925 mL 0.5850 mL 1.4625 mL
60 mM 0.0488 mL 0.2438 mL 0.4875 mL 1.2188 mL
80 mM 0.0366 mL 0.1828 mL 0.3656 mL 0.9141 mL
H2O 100 mM 0.0293 mL 0.1463 mL 0.2925 mL 0.7313 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dapoxetine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dapoxetine129938-20-1LY-210448LY210448LY 210448Serotonin Transporter5-HTTSERTSLC6A4Premature ejaculationPEsexual disorderBenignProstate HyperplasiaBPHserotonin reuptakeInhibitorinhibitorinhibit

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