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  4. Docusate Sodium

Docusate Sodium  (Synonyms: Dioctyl sulfosuccinate sodium salt)

Cat. No.: HY-B1268 Purity: ≥98.0%
COA Handling Instructions

Molarity Calculator

Docusate Sodium (Dioctyl sulfosuccinate sodium salt) is one of the main components in stool softeners. Docusate Sodium is a sulfated surfactant and may inactivate viral pathogens by disrupting viral envelopes and/or denaturing/disassociating proteins. Docusate Sodium is effective in vitro against wild type and drug-resistant strains of HSV type 1 and 2. Docusate Sodium is an obesogen. Docusate Sodium with developmental exposure leads to increased adult adiposity, inflammation, metabolic disorder and dyslipidemia in offspring fed a standard diet in mice.

For research use only. We do not sell to patients.

Docusate Sodium Chemical Structure

Docusate Sodium Chemical Structure

CAS No. : 577-11-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 66 In-stock
Solution
10 mM * 1 mL in Water USD 66 In-stock
Solid
100 mg USD 60 In-stock
500 mg USD 150 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Docusate Sodium:

Docusate Sodium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Docusate Sodium

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Docusate Sodium (Dioctyl sulfosuccinate sodium salt) is one of the main components in stool softeners. Docusate Sodium is a sulfated surfactant and may inactivate viral pathogens by disrupting viral envelopes and/or denaturing/disassociating proteins. Docusate Sodium is effective in vitro against wild type and drug-resistant strains of HSV type 1 and 2. Docusate Sodium is an obesogen. Docusate Sodium with developmental exposure leads to increased adult adiposity, inflammation, metabolic disorder and dyslipidemia in offspring fed a standard diet in mice[1][2].

IC50 & Target[1]

HSV-1

 

HSV-2

 

In Vivo

Docusate Sodium (Dioctyl sulfosuccinate sodium salt; 31.25 μg/mL; dissolved in water) in dams increases body mass, fat mass, fat percentage and reduces bone area in adult F1 male offspring[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant dams[2]
Dosage: 31.25 μg/mL
Administration: Dissolved in water
Result: F1 male offspring from DOSS-treated dams were significantly heavier than control male counterparts at 12 weeks and 16 weeks.
Molecular Weight

444.56

Formula

C20H37NaO7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC(CC)CCCC)C(S(=O)(O[Na])=O)CC(OCC(CC)CCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 20 mg/mL (44.99 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2494 mL 11.2471 mL 22.4942 mL
5 mM 0.4499 mL 2.2494 mL 4.4988 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (112.47 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (243 KB) HNMR (237 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.2494 mL 11.2471 mL 22.4942 mL 56.2354 mL
5 mM 0.4499 mL 2.2494 mL 4.4988 mL 11.2471 mL
10 mM 0.2249 mL 1.1247 mL 2.2494 mL 5.6235 mL
15 mM 0.1500 mL 0.7498 mL 1.4996 mL 3.7490 mL
20 mM 0.1125 mL 0.5624 mL 1.1247 mL 2.8118 mL
25 mM 0.0900 mL 0.4499 mL 0.8998 mL 2.2494 mL
30 mM 0.0750 mL 0.3749 mL 0.7498 mL 1.8745 mL
40 mM 0.0562 mL 0.2812 mL 0.5624 mL 1.4059 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Docusate Sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Docusate577-11-7Dioctyl sulfosuccinateHSVHerpes simplex virusstool softenerslipid emulsifierobesogenadiposityinflammationmetabolic disorderdyslipidemiaInhibitorinhibitorinhibit

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