2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Doxefazepam

Doxefazepam  (Synonyms: SAS-643)

Cat. No.: HY-101808 Purity: 99.99%
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Doxefazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsan and skeletal muscle relaxant properties.

For research use only. We do not sell to patients.

Doxefazepam Chemical Structure

Doxefazepam Chemical Structure

CAS No. : 40762-15-0

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5 mg USD 250 In-stock
10 mg USD 400 In-stock
25 mg USD 780 In-stock
50 mg USD 1250 In-stock
100 mg USD 1950 In-stock
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Based on 1 publication(s) in Google Scholar

Doxefazepam Related Antibodies

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Description

Doxefazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsan and skeletal muscle relaxant properties.

IC50 & Target

Benzodiazepine[1]
In Vivo

Groups of 50 male and 50 female Sprague-Dawley rats are given food containing sufficient Doxefazepam, a benzodiazepine derivative, to ensure intakes of 0, 3, 10, or 30 mg/kg/day. Rats are treated for 104 weeks and then euthanized. An extensive autopsy is performed on those animals that died intercurrently and on euthanized animals. The chronic administration of Doxefazepam does not influence the survival of the rats. A significant linear trend in the incidence of hepatocellular neoplasms, primarily benign, is observed in the female treated groups. This higher incidence is not associated to a higher occurrence of focal hyperplasia or other preneoplastic lesions in treated rats. The brain, a target organ for the pharmacological activity of Doxefazepam, is carefully examined to search for microscopic foci of proliferative cells. A total of 12 and 6 malignant gliomas are observed in male and female rats, respectively; only two are noticed at autopsy. These tumors are mainly of the oligodendroglioma type commonly found in aged rats[1]. Doxefazepam is investigated in a series of toxicological studies. Oral LD50 values are greater than 2000 mg/kg in mice, rats and dogs, while endoperitoneal LD50 values are 746 and 544 mg/kg in the mice and rats, respectively, and greater than 1000 mg/kg in the dogs[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

348.76

Formula

C17H14ClFN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CCO)C2=CC=C(Cl)C=C2C(C3=CC=CC=C3F)=NC1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (716.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8673 mL 14.3365 mL 28.6730 mL
5 mM 0.5735 mL 2.8673 mL 5.7346 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8673 mL 14.3365 mL 28.6730 mL 71.6825 mL
5 mM 0.5735 mL 2.8673 mL 5.7346 mL 14.3365 mL
10 mM 0.2867 mL 1.4337 mL 2.8673 mL 7.1683 mL
15 mM 0.1912 mL 0.9558 mL 1.9115 mL 4.7788 mL
20 mM 0.1434 mL 0.7168 mL 1.4337 mL 3.5841 mL
25 mM 0.1147 mL 0.5735 mL 1.1469 mL 2.8673 mL
30 mM 0.0956 mL 0.4779 mL 0.9558 mL 2.3894 mL
40 mM 0.0717 mL 0.3584 mL 0.7168 mL 1.7921 mL
50 mM 0.0573 mL 0.2867 mL 0.5735 mL 1.4337 mL
60 mM 0.0478 mL 0.2389 mL 0.4779 mL 1.1947 mL
80 mM 0.0358 mL 0.1792 mL 0.3584 mL 0.8960 mL
100 mM 0.0287 mL 0.1434 mL 0.2867 mL 0.7168 mL
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Doxefazepam Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Doxefazepam40762-15-0SAS-643SAS643SAS 643GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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