DuP 105

Cat. No.: HY-101726 Purity: 99.38%: FAQs
Data Sheet SDS COA Handling Instructions

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DuP 105 is an orally active oxazolidinone, a new class of synthetic antimicrobial agent with activity against gram-positive bacteria.

For research use only. We do not sell to patients.

DuP 105 Chemical Structure

CAS No. : 96800-41-8

Size	Price	Stock	Quantity
1 mg	USD 2489	In-stock	Estimated Time of Arrival: December 31
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10 mg		Get quote

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Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description

DuP 105 is an orally active oxazolidinone, a new class of synthetic antimicrobial agent with activity against gram-positive bacteria.

IC₅₀ & Target

Oxazolidinone

In Vitro

DuP 105 shows inhibitory activities against staphylococcal isolates and B. fragilis isolates with MIC₉₀s of 4 to 16 μg/mL and 16 μg/mL^[1]. DuP 105 MICs for 50% of the 216 gram-positive isolates tested (MIC₅₀s) range from 4.0 to 16 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DuP 105 administered by either the oral or the parenteral route is protective against staphylococcal and streptococcal infections in mice with the 50% effective doses of 9 to 23 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

296.34

Formula

C₁₃H₁₆N₂O₄S

CAS No.

96800-41-8

Appearance

Solid

Color

White to off-white

SMILES

CC(NC[C@H]1CN(C2=CC=C(S(C)=O)C=C2)C(O1)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (421.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3745 mL	16.8725 mL	33.7450 mL
5 mM	0.6749 mL	3.3745 mL	6.7490 mL
10 mM	0.3375 mL	1.6873 mL	3.3745 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.38%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (248 KB) HNMR (256 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Slee AM, et al. Oxazolidinones, a new class of synthetic antibacterial agents: in vitro and in vivo activities of DuP 105 and DuP 721. Antimicrob Agents Chemother. 1987 Nov;31(11):1791-7. [Content Brief]

[2]. Barry AL, et al. In vitro evaluation of DuP 105 and DuP 721, two new oxazolidinone antimicrobial agents. Antimicrob Agents Chemother. 1988 Jan;32(1):150-2. [Content Brief]

Animal Administration
^[1]

The mice are made neutropenic by the intraperitoneal administration of 100 mg of cyclophosphamide per kg on days -5, -3, and 0 (the day of infection). The extent of immunosuppression is assessed by using a standard hematological technique to determine leukocyte counts. In all experiments, the leukocyte count in the cyclophosphamide-treated mice is less than 15% of that in nontreated mice from day 0 through day 7. On day 0, the mice are injected intraperitoneally with a bacterial inoculum suspended in 0.2 mL of saline containing 5% gastric porcine mucin. This inoculum (2×10⁴ CFU) is fivefold that required to kill all the nontreated immunosuppressed mice in 48 h. Graded doses of the test compounds are administered by the subcutaneous or oral route at 1 and 4 h after infection. In parallel with the immunosuppressed mice, groups of nonimmunosuppressed mice are infected, and treated with the antibacterial drugs. The number of survivors on day 7 in each group is used to calculate the ED₅₀ values of the test compounds.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Slee AM, et al. Oxazolidinones, a new class of synthetic antibacterial agents: in vitro and in vivo activities of DuP 105 and DuP 721. Antimicrob Agents Chemother. 1987 Nov;31(11):1791-7. [Content Brief]

[2]. Barry AL, et al. In vitro evaluation of DuP 105 and DuP 721, two new oxazolidinone antimicrobial agents. Antimicrob Agents Chemother. 1988 Jan;32(1):150-2. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3745 mL	16.8725 mL	33.7450 mL	84.3626 mL
	5 mM	0.6749 mL	3.3745 mL	6.7490 mL	16.8725 mL
	10 mM	0.3375 mL	1.6873 mL	3.3745 mL	8.4363 mL
	15 mM	0.2250 mL	1.1248 mL	2.2497 mL	5.6242 mL
	20 mM	0.1687 mL	0.8436 mL	1.6873 mL	4.2181 mL
	25 mM	0.1350 mL	0.6749 mL	1.3498 mL	3.3745 mL
	30 mM	0.1125 mL	0.5624 mL	1.1248 mL	2.8121 mL
	40 mM	0.0844 mL	0.4218 mL	0.8436 mL	2.1091 mL
	50 mM	0.0675 mL	0.3375 mL	0.6749 mL	1.6873 mL
	60 mM	0.0562 mL	0.2812 mL	0.5624 mL	1.4060 mL
	80 mM	0.0422 mL	0.2109 mL	0.4218 mL	1.0545 mL
	100 mM	0.0337 mL	0.1687 mL	0.3375 mL	0.8436 mL

DuP 105 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DuP 10596800-41-8DuP105DuP-105BacterialAntibioticInhibitorinhibitorinhibit

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DuP 105

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