2. GPCR/G Protein
  3. GCGR
  4. Dulaglutide

Dulaglutide  (Synonyms: LY2189265)

Cat. No.: HY-P0120 Purity: ≥90.0%
COA Handling Instructions

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Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist. Dulaglutide can be uesd for the research of type 2 diabetes (T2D) .

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Dulaglutide Chemical Structure

Dulaglutide Chemical Structure

CAS No. : 923950-08-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Dulaglutide:

Dulaglutide Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Dulaglutide

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  • Customer Review

Description

Dulaglutide (LY2189265) is a glucagon-like peptide-1 (GLP-1) receptor agonist. Dulaglutide can be uesd for the research of type 2 diabetes (T2D) [1][2].

IC50 & Target

GLP-1 receptor[1]
In Vitro

Dulaglutide (50 nM and 100 nM; 24 h) ameliorates ox-LDL-induced oxidative stress and suppresses ox-LDL-induced mitochondrial dysfunction in human aortic endothelial cells (HAECs)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dulaglutide Related Antibodies

Cell Viability Assay[1]

Cell Line: Human aortic endothelial cells (HAECs)
Concentration: 50 nM, 100 nM
Incubation Time: 24 hous
Result: Suppressed ox-LDL-induced reduction of cell viability and release of lactate dehydrogenase (LDH).
In Vivo

Dulaglutide (0, 0.05, 0.5, 1.5, or 5 mg/kg; s.c.; twice week, for 93 weeks) increases the incidence of thyroid C-cell hyperplasia and neoplasia in the rat carcinogenicity study[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats and Transgenic mice[1]
Dosage: 0, 0.05, 0.5, 1.5, or 5 mg/kg; 0, 0.3, 1, or 3 mg/kg
Administration: SC, twice week, for 93 weeks; SC, twice week, for 26 weeks
Result: Statistically increased diffuse C-cell hyperplasia and adenomas at ＞0.5 mg/kg.
Decreased Systemic exposures over time in mice.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at 4°C, do not freeze
Purity & Documentation

Purity: ≥90.0%

COA (232 KB)

Handling Instructions (2659 KB)
References
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Dulaglutide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dulaglutide923950-08-7LY2189265LY 2189265LY-2189265GCGRGlucagon Receptorglucagon-like peptide-1 (GLP-1)receptor type 2 diabetes (T2D)Inhibitorinhibitorinhibit

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