2. GPCR/G Protein
  3. Platelet-activating Factor Receptor (PAFR)
  4. E-​6123

E-​6123 is a platelet-activating factor (PAF) receptor antagonist.

For research use only. We do not sell to patients.

E-​6123 Chemical Structure

E-​6123 Chemical Structure

CAS No. : 131614-02-3

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E-​6123 Related Antibodies

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Description

E-​6123 is a platelet-activating factor (PAF) receptor antagonist.

IC50 & Target

PAF[1]
In Vitro

E-6123 (E6123) partially inhibits the Thapsigargin-induced increase in the levels of interleukin-6 mRNA and interleukin-6 protein. To clarify the role of the concurrently produced cell-associated PAF in the thapsigargin-induced increase in the interleukin-6 mRNA level and interleukin-6 production, the effects of the PAF receptor antagonist E-6123 are examined. E-6123 at 1 and 10 μM partially inhibits the Thapsigargin (46.1 nM)-induced increase in the interleukin-6 mRNA level at 4 h and interleukin-6 production at 8 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

E-​6123 Related Antibodies
Molecular Weight

451.97

Formula

C23H22ClN5OS
CAS No.
SMILES

O=C(C1CC1)N2CC3=C(CC2)C(C(C4=CC=CC=C4Cl)=N[C@H]5C)=C(S3)N6C5=NN=C6C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Cell Assay
[1]

The viability of the cells is examined in each set of experiments by a procedure using MTT, which is based on the ability of mitochondrial succinate dehydrogenase to cleave MTT to the blue compound formazan. After the peritoneal cells are incubated for the periods indicated in 10 mL of medium containing the various drugs (e.g., E-6123), 1 mL of MTT solution in phosphate-buffered saline (5 mg/mL, pH 7.4) is added to each dish, and the cells are further incubated for 4 h at 37 °C. Next, 2.5 mL of 0.04 N HCl solution in isopropanol is added, and the cells are sonicated at 10% maximum power for 3 s. The resultant colored product is read on a Microplate Reader at 570 nm[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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E-​6123 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E-​6123131614-02-3Platelet-activating Factor Receptor (PAFR)Inhibitorinhibitorinhibit

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