2. GPCR/G Protein
  3. CRFR
  4. Emicerfont

Emicerfont  (Synonyms: GW876008)

Cat. No.: HY-14367 Purity: 98.03%
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Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM.

For research use only. We do not sell to patients.

Emicerfont Chemical Structure

Emicerfont Chemical Structure

CAS No. : 786701-13-1

Size Price Stock Quantity
5 mg USD 620 In-stock
10 mg USD 980 In-stock
25 mg USD 1950 In-stock
50 mg USD 3250 In-stock
100 mg USD 5200 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Emicerfont Related Antibodies

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Description

Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM.

IC50 & Target

IC50: 66 nM (CRF1 receptor)[1]
In Vitro

Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Emicerfont Related Antibodies
In Vivo

At concentration of 10 mg/kg, Emicerfont reduces i.c.v. CRF-induced gerbil forepaw treading and marmoset defensive postures. Emicerfont also reduces rat pup ultrasonic vocalization at concentration of 30 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

404.46

Formula

C22H24N6O2
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

CC1=CC(OC)=CC=C1N(CC2)C3=C2C(N4C=CC(N5CCN([H])C5=O)=N4)=CC(C)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DCM : ≥ 16.67 mg/mL (41.22 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4724 mL 12.3622 mL 24.7243 mL
5 mM 0.4945 mL 2.4724 mL 4.9449 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DCM 1 mM 2.4724 mL 12.3622 mL 24.7243 mL 61.8108 mL
5 mM 0.4945 mL 2.4724 mL 4.9449 mL 12.3622 mL
10 mM 0.2472 mL 1.2362 mL 2.4724 mL 6.1811 mL
15 mM 0.1648 mL 0.8241 mL 1.6483 mL 4.1207 mL
20 mM 0.1236 mL 0.6181 mL 1.2362 mL 3.0905 mL
25 mM 0.0989 mL 0.4945 mL 0.9890 mL 2.4724 mL
30 mM 0.0824 mL 0.4121 mL 0.8241 mL 2.0604 mL
40 mM 0.0618 mL 0.3091 mL 0.6181 mL 1.5453 mL
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Emicerfont Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emicerfont786701-13-1GW876008GW 876008GW-876008CRFRCorticotropin-releasing Factor ReceptorCRHRInhibitorinhibitorinhibit

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