Esomeprazole potassium salt (Synonyms: (S)-Omeprazole potassium salt; (-)-Omeprazole potassium salt)

Cat. No.: HY-17021B Purity: 98.18%: FAQs
Data Sheet SDS COA Handling Instructions

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Esomeprazole potassium salt ((S)-Omeprazole potassium salt) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H⁺, K⁺-ATPase in gastric parietal cells. Esomeprazole potassium salt has the potential for symptomatic gastroesophageal reflux disease research.

For research use only. We do not sell to patients.

Esomeprazole potassium salt Chemical Structure

CAS No. : 161796-84-5

Size	Price	Stock	Quantity
1 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 285	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

H⁺, K⁺-ATPase^[1]^[2]

In Vitro

Esomeprazole (25-100 µM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MDA-MB-468 cells
Concentration:	25 µM, 50 µM, 75 µM, 100 µM
Incubation Time:	20 hours
Result:	Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner.

In Vivo

Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury^[2]
Dosage:	30 mg/kg, 300 mg/kg
Administration:	Oral gavage; daily; for 19 or 11 days
Result:	Significantly inhibited the progression of fibrosis throughout the lungs of the animals.

Clinical Trial

Molecular Weight

383.51

Formula

C₁₇H₁₈KN₃O₃S

CAS No.

161796-84-5

Appearance

Solid

Color

White to off-white

SMILES

O=[S@](C1=NC2=CC=C(OC)C=C2[N-]1)CC3=NC=C(C)C(OC)=C3C.[K+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : 38.35 mg/mL (100.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6075 mL	13.0375 mL	26.0749 mL
5 mM	0.5215 mL	2.6075 mL	5.2150 mL
10 mM	0.2607 mL	1.3037 mL	2.6075 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.18%

Select Batch:

Data Sheet (274 KB) SDS (392 KB)

COA (248 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17(3):439-46. [Content Brief]

[2]. Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16. [Content Brief]

[3]. Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6075 mL	13.0375 mL	26.0749 mL	65.1873 mL
	5 mM	0.5215 mL	2.6075 mL	5.2150 mL	13.0375 mL
	10 mM	0.2607 mL	1.3037 mL	2.6075 mL	6.5187 mL
	15 mM	0.1738 mL	0.8692 mL	1.7383 mL	4.3458 mL
	20 mM	0.1304 mL	0.6519 mL	1.3037 mL	3.2594 mL
	25 mM	0.1043 mL	0.5215 mL	1.0430 mL	2.6075 mL
	30 mM	0.0869 mL	0.4346 mL	0.8692 mL	2.1729 mL
	40 mM	0.0652 mL	0.3259 mL	0.6519 mL	1.6297 mL
	50 mM	0.0521 mL	0.2607 mL	0.5215 mL	1.3037 mL
	60 mM	0.0435 mL	0.2173 mL	0.4346 mL	1.0865 mL
	80 mM	0.0326 mL	0.1630 mL	0.3259 mL	0.8148 mL

Esomeprazole potassium salt Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Esomeprazole161796-84-5(S)-Omeprazole(-)-OmeprazoleProton PumpBacterialCYP3A4H+K+-ATPaseantacidanti-inflammationfibrosisgastroesophagealInhibitorinhibitorinhibit

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