Fabomotizole hydrochloride (Synonyms: CM346 hydrochloride)

Cat. No.: HY-14895A Purity: 99.95%: FAQs
Data Sheet SDS COA Handling Instructions

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Fabomotizole hydrochloride (CM346 hydrochloride) is an anxiolytic agent. Fabomotizole hydrochloride produces anxiolytic and neuroprotective effects without any muscle relaxant actions.

For research use only. We do not sell to patients.

Fabomotizole hydrochloride Chemical Structure

CAS No. : 173352-39-1

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 77	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 77	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 265	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 750	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of Fabomotizole hydrochloride:

Fabomotizole Get quote
Fabomotizole di(hydrochloride) Get quote

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Biological Activity
Purity & Documentation
References
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Description

Fabomotizole hydrochloride (CM346 hydrochloride) is an anxiolytic agent. Fabomotizole hydrochloride produces anxiolytic and neuroprotective effects without any muscle relaxant actions.

In Vitro

Afobazole's mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Afobazole has found little clinical use outside of Russia and has not been evaluated by the FDA.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

343.87

Formula

C₁₅H₂₂ClN₃O₂S

CAS No.

173352-39-1

Appearance

Solid

Color

Light yellow to yellow

SMILES

CCOC1=CC=C2C(N=C(SCCN3CCOCC3)N2)=C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (290.81 mM; Need ultrasonic)

DMSO : ≥ 44 mg/mL (127.96 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9081 mL	14.5404 mL	29.0808 mL
5 mM	0.5816 mL	2.9081 mL	5.8162 mL
10 mM	0.2908 mL	1.4540 mL	2.9081 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (145.40 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.95%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (247 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Afobazole, From Wikipedia

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.9081 mL	14.5404 mL	29.0808 mL	72.7019 mL
	5 mM	0.5816 mL	2.9081 mL	5.8162 mL	14.5404 mL
	10 mM	0.2908 mL	1.4540 mL	2.9081 mL	7.2702 mL
	15 mM	0.1939 mL	0.9694 mL	1.9387 mL	4.8468 mL
	20 mM	0.1454 mL	0.7270 mL	1.4540 mL	3.6351 mL
	25 mM	0.1163 mL	0.5816 mL	1.1632 mL	2.9081 mL
	30 mM	0.0969 mL	0.4847 mL	0.9694 mL	2.4234 mL
	40 mM	0.0727 mL	0.3635 mL	0.7270 mL	1.8175 mL
	50 mM	0.0582 mL	0.2908 mL	0.5816 mL	1.4540 mL
	60 mM	0.0485 mL	0.2423 mL	0.4847 mL	1.2117 mL
	80 mM	0.0364 mL	0.1818 mL	0.3635 mL	0.9088 mL
	100 mM	0.0291 mL	0.1454 mL	0.2908 mL	0.7270 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Fabomotizole hydrochloride Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fabomotizole173352-39-1CM346CM 346CM-346OthersInhibitorinhibitorinhibit

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