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  4. Gelucire 44/14

Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable agents including insulin and calcitonin by pulmonary delivery.

For research use only. We do not sell to patients.

Gelucire 44/14 Chemical Structure

Gelucire 44/14 Chemical Structure

CAS No. : 121548-04-7

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Gelucire 44/14 Related Antibodies

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1 Publications Citing Use of MCE Gelucire 44/14

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Description

Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable agents including insulin and calcitonin by pulmonary delivery.

In Vivo

Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable drugs including insulin and calcitonin by pulmonary delivery. It is found that pulmonary absorptions of FD4, FD10 and FD70 are enhanced in different degree by Gelucire 44/14 in a concentration-dependent manner, and the maximal absorption-enhancing effect is obtained when the concentration of Gelucire 44/14 reaches to 2.0% (w/v). It is also found that the absorption enhancing ability of Gelucire Gelucire 44/14 is correlated with the molecular weight of model drugs, and the highest absorption enhancement ratio of Gelucire Gelucire 14/44 is observed when the molecular weight of model drugs reaches to nearly 10000 Da[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CAS No.
Appearance

Oil

Color

Off-white to light yellow

SMILES

[Gelucire 44/14]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (Need ultrasonic)

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Purity & Documentation

Purity: ≥96.0%

COA (245 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[1]

Male Sprague Dawley rats are used to evaluate the pulmonary membrane toxicity of Gelucire 44/14. PBS (pH 7.4) with or without Gelucire 44/14 are directly administered to the tracheae of the rats according to the in-situ pulmonary absorption experiments. Four hours later, the rats are bled from the abdominal aorta, and then PBS (pH7.4) is perfused into the rat lung along the trachea. Afterwards, bronchoalveolar lavage fluid (BALF) of rat in each group is collected and kept in ice immediately until determination[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Gelucire 44/14 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gelucire 44/14121548-04-7Biochemical Assay ReagentsInhibitorinhibitorinhibit

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