H-Ile-Pro-Pro-OH

Cat. No.: HY-114424: FAQs
Data Sheet Handling Instructions

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H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC₅₀ of 5 μM. Antihypertensive tripeptides.

For research use only. We do not sell to patients.

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H-Ile-Pro-Pro-OH Chemical Structure

CAS No. : 26001-32-1

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Other Forms of H-Ile-Pro-Pro-OH:

H-Ile-Pro-Pro-OH hydrochloride Get quote

1 Publications Citing Use of MCE H-Ile-Pro-Pro-OH

•J Physiol Biochem. 2024 Jul 15. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description	H-Ile-Pro-Pro-OH, a milk-derived peptide^[1], inhibits angiotensin-converting enzyme (ACE)^[1] with an IC₅₀ of 5 μM^[2]. Antihypertensive tripeptides^[1].
IC₅₀ & Target	IC50: 5 μM (ACE)^[2]
In Vitro	Ile-Pro-Pro (IPP; 1 nM, 0.1 μM, and 10 μM) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. H-Ile-Pro-Pro-OH Related Antibodies
In Vivo	Ile-Pro-Pro (IPP; 30 mg/kg per day; 0.3 g/L) attenuates arterial dysfunction in L-NAME-treated rats^[1] Ile-Pro-Pro decreases blood pressure in spontaneously hypertensive rats (SHR) ^[1]. Ile-Pro-Pro attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	325.40
Formula	C₁₆H₂₇N₃O₄
CAS No.	26001-32-1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. Nonaka A, et al. The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats. Hypertens Res. 2014 Aug;37(8):703-7. [Content Brief] [2]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83. [Content Brief]

H-Ile-Pro-Pro-OH Related Classifications

Cardiovascular Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H-Ile-Pro-Pro-OH26001-32-1Angiotensin-converting Enzyme (ACE)milk-derivedAntihypertensivetripeptideInhibitorinhibitorinhibit

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